Targeting senescence as an anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13312
Abstract: Cellular senescence is a stress response elicited by different molecular insults. Senescence results in cell cycle exit and is characterised by multiple phenotypic changes such as the production of a bioactive secretome. Senescent cells accumulate… read more here.
Keywords: one two; senescence; senescent cells; anticancer ... See more keywords
A One-Two Punch in the Gut May Trigger Multiple Sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.016
Abstract: The microbiome plays an important role in multiple sclerosis. In a recent issue of Nature, Miyauchi et al. report that gut microbial molecular mimicry in concert with gut microbes that enhance Th17 cells act synergistically to… read more here.
Keywords: sclerosis; one two; punch gut; multiple sclerosis ... See more keywords
A catalytic one-two punch
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaz6166
Abstract: Cooperative catalysis enables the controlled synthesis of unnatural amino acids Amino acids are the building blocks of proteins, and chemists use these difunctional molecules for the laboratory synthesis of a wide variety of useful chiral… read more here.
Keywords: two punch; one two; amino acids; catalytic one ... See more keywords
The One-Two Punch of Delirium and Dementia During the COVID-19 Pandemic and Beyond
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2020.596218
Abstract: While the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is an unprecedented threat to all of us, older adults are especially at risk for serious complications from coronavirus disease 2019 (COVID-19) that necessitate hospitalization… read more here.
Keywords: one two; dementia; two punch; delirium ... See more keywords
Premature MicroRNA-Based Therapeutic: A “One-Two Punch” against Cancers
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123831
Abstract: Simple Summary The current understanding of miRNA biology is greatly derived from studies on the guide strands and the passenger strands, also called miRNAs*, which are considered as carriers with no sense for long periods.… read more here.
Keywords: cancers premature; one two; biology; expression ... See more keywords