Administration of nivolumab plus ipilimumab: Infusion of the fixed‐ratio combination versus sequential infusions in two randomized controlled trials of metastatic melanoma (CheckMate 742) and renal cell carcinoma (CheckMate 800)
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DOI: 10.1002/cncr.35962
Abstract: Immune checkpoint inhibitors can be coadministered as a fixed‐ratio combination (FRC) or administered as sequential infusions (ASI). Two randomized, open‐label trials compared nivolumab + ipilimumab as a FRC versus ASI in patients with melanoma or… read more here.
Keywords: checkmate; renal cell; two randomized; sequential infusions ... See more keywords
Teprotumumab for Graves’ orbitopathy and ototoxicity: moving problems from eyes to ears?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-022-01791-w
Abstract: Graves’ orbitopathy (GO) is an autoimmune orbital disease mostly associated with Graves’ hyperthyroidism, causing disfiguring signs (exophthalmos, periorbital swelling, strabismus) and relevant symptoms (diplopia, tearing, photophobia, and [rarely] sight loss) [1]. While the majority of… read more here.
Keywords: two randomized; teprotumumab; drug; randomized clinical ... See more keywords
Effectiveness of the Thinking Healthy Programme for perinatal depression delivered through peers: Pooled analysis of two randomized controlled trials in India and Pakistan.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2019.11.110
Abstract: BACKGROUND The Thinking Healthy Programme (THP) is recommended to treat perinatal depression in resource-limited settings, but scale-up is hampered by a paucity of community health workers. THP was adapted for peer-delivery (THPP) and evaluated in… read more here.
Keywords: two randomized; healthy programme; depression; randomized controlled ... See more keywords
Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials
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DOI: 10.1111/adb.13125
Abstract: Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including subjective drug effects and behavioural effects, and cannabinoid pharmacokinetics. This is significant given current changes to cannabis‐related policies… read more here.
Keywords: sex differences; two randomized; acute cannabis; cannabis effects ... See more keywords
Tildrakizumab efficacy and impact on quality of life up to 52 weeks in patients with moderate‐to‐severe psoriasis: a pooled analysis of two randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.15862
Abstract: Two randomized controlled trials (reSURFACE 1 and 2) have demonstrated the effectiveness of tildrakizumab, a high‐affinity, humanized, IgG1κ, anti‐interleukin‐23 monoclonal antibody, for treating moderate‐to‐severe plaque psoriasis in the first 28 weeks. read more here.
Keywords: two randomized; randomized controlled; tildrakizumab efficacy; psoriasis ... See more keywords
Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201811-2081le
Abstract: The human nasopharynx is frequently colonized by Streptococcus pneumoniae (the pneumococcus), serving as the reservoir for transmission, a state which necessarily precedes invasive pneumococcal infection. Influenza infection increases pneumococcal colonization density and dysregulates host immune… read more here.
Keywords: two randomized; trials effect; colonization; pneumococcal colonization ... See more keywords
Cardiometabolic and immune response to exercise training in patients with metabolic syndrome: retrospective analysis of two randomized clinical trials
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DOI: 10.3389/fcvm.2024.1329633
Abstract: Background Metabolic syndrome (MetS) is defined by the presence of central obesity plus ≥two metabolic/cardiovascular risk factors (RF), with inflammation being a major disease-driving mechanism. Structured endurance exercise training (ET) may positively affect these traits,… read more here.
Keywords: two randomized; response; exercise training; exercise ... See more keywords
Dietary Modifications in IBS Leads to Reduced Symptoms, Weight, and Lipid Levels: Two Randomized Clinical Trials
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DOI: 10.3390/nu17182966
Abstract: Background/Objectives: Irritable bowel syndrome (IBS) is presented with both gastrointestinal and extraintestinal symptoms. In addition, overweight/obesity and metabolic syndrome is prevalent in IBS. Dietary interventions with a low content of fermentable oligo-, di-, and monosaccharides… read more here.
Keywords: lipid levels; symptoms weight; two randomized; ibs ... See more keywords