Two steps are better than one: improving gene editing to treat cancer
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13342
Abstract: Gene editing enables scientists to make precise changes to the genome of an organism using the cell’s own ability to repair damaged DNA using a supplied DNA template. In recent years, gene editing has been… read more here.
Keywords: dna; cancer; two steps; steps better ... See more keywords
Different polishing methods for zirconia: impact on surface, optical, and mechanical properties
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02953-6
Abstract: Objectives To test the impact of polishing strategies on zirconia properties. Materials and methods One hundred eight zirconia specimens were divided into nine groups ( n = 12/group). Seven groups were polished in the white-stage with… read more here.
Keywords: two steps; white stage; surface; stage polishing ... See more keywords
A two steps membrane process for the recovery of succinic acid from fermentation broth
Sign Up to like & getrecommendations! Published in 2018 at "Separation and Purification Technology"
DOI: 10.1016/j.seppur.2018.06.056
Abstract: The aim of this study was to investigate the integration of nanofiltration in succinic acid production based on a fermentation. An experimental investigation was carried out with NF 45 membrane and synthetic fermentation broths of… read more here.
Keywords: succinic acid; two steps; fermentation; steps membrane ... See more keywords
Two Steps to Bicyclo[4.2.0]octadienes from Cyclooctatetraene: Total Synthesis of Kingianic Acid A.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00325
Abstract: Synthetic approaches to bicyclo[4.2.0]octadiene natural products frequently employ the synthesis of linear tetraenes to initiate a biosynthetic 8π/6π-electrocyclization cascade. This work forges a functionalized bicyclo[4.2.0]octadiene in two steps from cyclooctatetraene. The versatility of this method… read more here.
Keywords: two steps; kingianic acid; synthesis kingianic; synthesis ... See more keywords
Trapping of a Terminal Intermediate in the Boron-Mediated Dinitrogen Reduction: Mono-, Tri-, and Tetrafunctionalized Hydrazines in Two Steps from N2.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c01818
Abstract: The addition of chlorotrimethylsilane to a boron-mediated, transition-metal-free N2 activation reaction leads to the isolation of multiple potassium boryl(silyl)hydrazido species, likely trapping products of a terminal dinitrogen complex of boron. One of these silylated N2… read more here.
Keywords: boron mediated; tetrafunctionalized hydrazines; two steps; boron ... See more keywords
Nature journals announce two steps to improve transparency
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-02563-4
Abstract: Reporting summaries help authors to provide important details before review. Reporting summaries help authors to provide important details before review. read more here.
Keywords: nature journals; announce two; two steps; improve transparency ... See more keywords
Cardiac fibrosis research: two steps forward
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-019-0245-7
Abstract: Two studies reporting novel insights into fibroblast identity and activation dynamics provide an important step forward in our understanding of cardiac fibrosis and the quest to develop new anti-fibrotic strategies read more here.
Keywords: steps forward; research two; two steps; fibrosis ... See more keywords
The evolution of hominin bipedalism in two steps
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-09399-9
Abstract: Bipedalism is a human-defining trait1, 2–3. It is made possible by the familiar, bowl-shaped pelvis, whose short, wide iliac blades curve along the sides of the body to stabilize walking and support internal organs and… read more here.
Keywords: bipedalism; two steps; hominin bipedalism; bipedalism two ... See more keywords
Supramolecular chirality of amphiphilic block copolymer films made through two steps: self-assembling first, and then solution coating.
Sign Up to like & getrecommendations! Published in 2017 at "Soft matter"
DOI: 10.1039/c7sm01635b
Abstract: Supramolecular chirality is achieved in amphiphilic block copolymer films made through two-step fabrication: self-assembling first and then solution coating. The amphiphilic block copolymer is composed of poly(N-isopropyl acrylamide) (pNIPAM) as hydrophilic segments and poly(methyl methacrylate)… read more here.
Keywords: two steps; block copolymer; amphiphilic block; solution ... See more keywords
“Two‐steps” seed‐derived plugs as an effective propagation method for the establishment of Miscanthus in saline–alkaline soil
Sign Up to like & getrecommendations! Published in 2021 at "GCB Bioenergy"
DOI: 10.1111/gcbb.12820
Abstract: Miscanthus, a perennial rhizomatous C4 grass, has emerged as a promising lignocellulosic crop. To avoid competition with food crops, marginal lands especially saline–alkaline soil are being recommended to grow Miscanthus across China. However, the challenges… read more here.
Keywords: propagation; seed; two steps; saline alkaline ... See more keywords
Two steps forward—now look back
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.370.6523.1428-g
Abstract: Directed Evolution Whether designed computationally or uncovered in activity screening, enzymes repurposed for biocatalysis rarely start at the peak of proficiency. However, directed evolution can in some cases increase catalytic efficiency of a poor enzyme… read more here.
Keywords: science; steps forward; look back; two steps ... See more keywords