Novel two‐tiered screening approach identifies synergistic combinations of natural compounds for prostate cancer prevention and treatment
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23674
Abstract: Prostate cancer (PCa) is the second most common cancer type among American men and it is estimated that in 2023, 34,700 men will die from PCa. Since it can take a considerable amount of time… read more here.
Keywords: cancer; synergistic combinations; prostate cancer; pca ... See more keywords
Bearing capacity and failure mechanisms of two-tiered reinforced soil retaining walls under footing load
Sign Up to like & getrecommendations! Published in 2020 at "Computers and Geotechnics"
DOI: 10.1016/j.compgeo.2020.103833
Abstract: Abstract The paper presents a numerical modeling study on the bearing capacity of two-tiered reinforced soil retaining walls. Numerical simulations are carried out using the finite element limit analysis (FELA) method, which is validated against… read more here.
Keywords: bearing capacity; soil retaining; capacity; two tiered ... See more keywords
High-Sensitivity Cell-Based Plasmonic Biolayer Interferometry with a Two-Tiered Enhancement for Clinical Autoimmunity Surveillance of Pemphigus Vulgaris.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.4c12485
Abstract: Pemphigus vulgaris (PV) is a chronic, often fatal autoimmune blistering disorder that affects the skin and body-wide mucous membranes, imperatively urging for accurate detection of characteristic autoantibodies. To overcome the sensitivity constraint, we report here… read more here.
Keywords: pemphigus vulgaris; based plasmonic; plasmonic biolayer; cell based ... See more keywords
A two-tiered targeted proteomics approach to identify pre-diagnostic biomarkers of colorectal cancer risk
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-83968-6
Abstract: Colorectal cancer prognosis is dependent on stage, and measures to improve early detection are urgently needed. Using prospectively collected plasma samples from the population-based Northern Sweden Health and Disease Study, we evaluated protein biomarkers in… read more here.
Keywords: two tiered; colorectal cancer; cancer risk; tiered targeted ... See more keywords
Unveiling the helicity switching mechanism of a rigid two-tiered stacked architecture
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c8ra09226e
Abstract: The conformational switching process of a rigid two-tiered stacked architecture has been revealed at the atomic level with the aid of molecular dynamic simulations and free-energy calculations. read more here.
Keywords: rigid two; tiered stacked; two tiered; stacked architecture ... See more keywords
Comparing two-tiered and multi-tiered grading approaches: students’ perspectives
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Further and Higher Education"
DOI: 10.1080/0309877x.2025.2456928
Abstract: ABSTRACT This study investigates medical student perspectives of two-tiered grading and multi-tiered grading systems across their academic program. It is unique in its kind as the participants in this study experienced both grading systems at… read more here.
Keywords: multi tiered; tiered grading; students perspectives; two tiered ... See more keywords
Modified Two-Tiered Testing Enzyme Immunoassay Algorithm for Serologic Diagnosis of Lyme Disease
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac272
Abstract: Abstract The modified 2-tier testing algorithm (MTTT) for Lyme disease (LD) has been approved by the US Food and Drug Administration. In this study, we show that the MTTT detected 28% more cases of early… read more here.
Keywords: disease; modified two; two tiered; lyme disease ... See more keywords
Multicenter Clinical Evaluation of Modified Two-Tiered Testing Algorithms for Lyme Disease Using Zeus Scientific Commercial Assays
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.02528-21
Abstract: Modified two-tiered testing (MTTT) algorithms for Lyme disease (LD), which involve the sequential use of orthogonal enzyme immunoassays (EIAs) without immunoblotting, are acceptable alternatives to standard two-tiered testing (STTT; EIA followed by immunoblots) provided the… read more here.
Keywords: disease; modified two; two tiered; tiered testing ... See more keywords
A two–tiered system for selective receptor and transporter protein degradation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010446
Abstract: Diverse physiology relies on receptor and transporter protein down–regulation and degradation mediated by ESCRTs. Loss–of–function mutations in human ESCRT genes linked to cancers and neurological disorders are thought to block this process. However, when homologous… read more here.
Keywords: transporter protein; transporter; two tiered; receptor transporter ... See more keywords