Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by downregulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200452
Abstract: BACKGROUNDS/AIMS This study explores the potential of chronic treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks… read more here.
Keywords: txa2 pathway; iso; cox txa2; cirrhotic rats ... See more keywords
Sildenafil (Viagra®) Prevents Cox-1/ TXA2 Pathway-Mediated Vascular Hypercontractility in ApoE-/- Mice
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000485817
Abstract: Background/Aims: The atherosclerotic apolipoprotein E-deficient (apoE-/-) mouse exhibits impaired vasodilation and enhanced vasoconstriction responsiveness. The objectives of this study were: a) to determine the relative contribution of cyclooxygenases (Cox-1 and Cox-2), thromboxane A2 (TXA2) and… read more here.
Keywords: txa2 pathway; cox txa2; sildenafil; mice ... See more keywords