Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor
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DOI: 10.3390/md16060215
Abstract: α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing… read more here.
Keywords: methionine; nicotinic acetylcholine; conotoxin txid; txid ... See more keywords
Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID
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DOI: 10.3390/md21050286
Abstract: α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively. In order to identify the effects… read more here.
Keywords: potency; txid; conotoxin txid; conotoxin ... See more keywords