Exploring Thioredoxin‐Interacting Protein (TXNIP) as a Therapeutic Target for Cardiovascular Diseases
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DOI: 10.1002/ardp.70082
Abstract: Cardiovascular diseases (CVDs) are the primary causes of death globally. Risk factors such as aging, poor lifestyle, and genetics significantly influence how these diseases progress, with oxidative stress being an important factor in their pathogenesis.… read more here.
Keywords: therapeutic target; txnip; cardiovascular diseases; interacting protein ... See more keywords
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA‐223/TXNIP/Wnt/β‐catenin pathway
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DOI: 10.1002/iub.2450
Abstract: Dysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of… read more here.
Keywords: cervical cancer; histone deacetylase; catenin pathway; txnip ... See more keywords
LncRNA FOXD3‐AS1 aggravates myocardial ischemia/reperfusion injury by inactivating the Redd1/AKT/GSK3β/Nrf2 signaling pathway via the miR‐128/TXNIP axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23218
Abstract: Long noncoding RNA forkhead box D3‐antisense RNA 1 (FOXD3‐AS1) is associated with cardiovascular diseases, but its roles in myocardial ischemia/reperfusion (I/R) injury and the related signaling pathway have not been fully reported. We aimed to… read more here.
Keywords: txnip; foxd3 as1; injury; mir 128 ... See more keywords
Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas
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DOI: 10.1007/s10147-017-1103-4
Abstract: BackgroundThe redox regulatory protein, thioredoxin-interacting protein (TXNIP), has been confirmed as an important tumor suppressor gene in various types of human cancers. In previous studies, we found that overexpression of tumor suppressor gene RIZ1 in… read more here.
Keywords: recurrence; expression txnip; thioredoxin interacting; expression ... See more keywords
miR-146a-5p/TXNIP axis attenuates intestinal ischemia-reperfusion injury by inhibiting autophagy via the PRKAA/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114839
Abstract: Autophagy is being increasingly recognized as an important regulator of intestinal ischemia-reperfusion(I/R)injury, but its exact role is still debated. Emerging evidence suggests that miR-146a-5p is involved in the initiation and development of I/R injury, but… read more here.
Keywords: prkaa mtor; mir 146a; via prkaa; txnip ... See more keywords
The pivotal role of extracellular signal-regulated kinase in gap junction-mediated regulation of TXNIP.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.07.001
Abstract: Gap junctions (GJs) play a major role in the control of cell structure, function, and metabolism. However, the molecular mechanisms involved are still poorly understood. Given that thioredoxin-interacting protein (TXNIP) regulates a broad range of… read more here.
Keywords: kinase; erk; extracellular signal; regulated kinase ... See more keywords
TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118988
Abstract: AIMS Diabetic retinopathy (DR) can cause vision loss in patients with diabetes. The present study evaluated the expression of thioredoxin interacting protein (TXNIP) and investigated the role of TXNIP in autophagy and apoptosis of DR.… read more here.
Keywords: autophagy apoptosis; ller cell; txnip; cell ... See more keywords
Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome.
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DOI: 10.1016/j.molimm.2021.03.004
Abstract: OBJECTIVE To explore the role of Forsythoside I (FI) in acute lung injury (ALI) mouse and its underling mechanism. METHODS The cell models of ALI are constructed by LPS induction. After pretreatment with different concentrations… read more here.
Keywords: lung injury; txnip nlrp3; txnip; acute lung ... See more keywords
Role of Thioredoxin-Interacting Protein in Diabetic Fatty Kidney Induced by Advanced Glycation End-Products.
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DOI: 10.1021/acs.jafc.1c03559
Abstract: Advanced glycation end-products (AGEs) have been identified as the etiological factors associated with the fatty kidney. Thioredoxin-interacting protein (TXNIP) might be a mediator involved in AGE-induced fatty kidney. This study focused on investigating how TXNIP… read more here.
Keywords: age; fatty kidney; glycation end; advanced glycation ... See more keywords
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction
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DOI: 10.1038/s41374-018-0078-8
Abstract: Thioredoxin-interacting protein (TXNIP) is associated with inflammation, tubulointerstitial fibrosis, and oxidative stress in diabetic kidney disease, yet the potential role of TXNIP in nondiabetic renal injury is not well known. This study aimed to investigate… read more here.
Keywords: unilateral ureteral; fibrosis; inflammation; thioredoxin interacting ... See more keywords
C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism
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DOI: 10.1038/s41388-020-01593-5
Abstract: Chronic hepatitis B virus (HBV) infection is strongly associated with the initiation and development of hepatocellular carcinoma (HCC). However, the genetic alterations and pathogenesis mechanisms remain significantly unexplored, especially for HBV-induced metabolic reprogramming. Analysis of… read more here.
Keywords: txnip; terminal truncated; glucose metabolism; hbx ... See more keywords