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   Articles with "txnip nlrp3" as a keyword



Ferulic acid relieved ulcerative colitis by inhibiting the TXNIP/NLRP3 pathway in rats

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11935

Abstract: Ulcerative colitis (UC) is a disorder of the bowel that is characterized by a chronic inflammatory response. The traditional Chinese herbal medicine ferulic acid (FA) is known for its antioxidant, antiapoptotic, and antiinflammatory properties. However,… read more here.

Keywords: nlrp3 signaling; ulcerative colitis; pathway; txnip nlrp3 ... See more keywords

Canagliflozin Attenuates Podocyte Inflammatory Injury through Suppressing the TXNIP/NLRP3 Signaling Pathway in Diabetic Kidney Disease Mice

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recommendations! Published in 2025 at "Inflammation"

DOI: 10.1007/s10753-025-02258-9

Abstract: Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), poses a serious threat to global health. Aseptic inflammation and pyroptosis of podocytes are crucial factors contributing to the pathogenesis and progression of… read more here.

Keywords: mice; disease; txnip nlrp3; diabetic kidney ... See more keywords

Chronic Ketosis Provides Neuroprotection Through HIF- 1α-Mediated Control of the TXNIP/NLRP3 Axis by Regulating the Inflammatory and Apoptotic Response

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recommendations! Published in 2025 at "Molecular Neurobiology"

DOI: 10.1007/s12035-025-04943-0

Abstract: We and others have previously demonstrated that hypoxia-inducible factor alpha (HIF-1α) stabilization through diet-induced ketosis plays a vital role during brain ischemic injury. We have recently reported that ketosis-stabilized HIF-1α regulates the inflammatory response and… read more here.

Keywords: ketosis; brain; chronic ketosis; txnip nlrp3 ... See more keywords

Salidroside alleviates high glucose-induced oxidative stress and extracellular matrix accumulation in rat glomerular mesangial cells by the TXNIP-NLRP3 inflammasome pathway.

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recommendations! Published in 2017 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2017.10.012

Abstract: Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major ingredient in Rhodiola rosea and possesses beneficial effects on DN. This study aimed… read more here.

Keywords: accumulation; sal; txnip nlrp3; nlrp3 inflammasome ... See more keywords

Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome.

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recommendations! Published in 2021 at "Molecular immunology"

DOI: 10.1016/j.molimm.2021.03.004

Abstract: OBJECTIVE To explore the role of Forsythoside I (FI) in acute lung injury (ALI) mouse and its underling mechanism. METHODS The cell models of ALI are constructed by LPS induction. After pretreatment with different concentrations… read more here.

Keywords: lung injury; txnip nlrp3; txnip; acute lung ... See more keywords

Metformin modulates the TXNIP-NLRP3-GSDMD pathway to improve diabetic bladder dysfunction

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-72129-0

Abstract: To validate the therapeutic efficacy of metformin on diabetic bladder dysfunction (DBD) and further elucidate whether the TXNIP-NLRP3-GSDMD axis serves as a target for metformin in ameliorating DBD. C57BL/6J mice were induced with diet-induced obesity… read more here.

Keywords: mice; txnip nlrp3; gsdmd; bladder ... See more keywords

The size-dependence and reversibility of polystyrene nanoplastics-induced hepatic pyroptosis in mice through TXNIP/NLRP3/GSDMD pathway.

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recommendations! Published in 2024 at "Toxicology research"

DOI: 10.1093/toxres/tfae106

Abstract: As emerging environmental contaminants, nanoplastics (NPs) are progressively accumulating in terrestrial and aquatic ecosystems worldwide, posing a potential threat to human health. The liver is considered as one of the primary organs targeted by NPs… read more here.

Keywords: pyroptosis; txnip; txnip nlrp3; gsdmd ... See more keywords

Effects of Hypoxic Environment on Periodontal Tissue through the ROS/TXNIP/NLRP3 Inflammasome Pathway

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/7690960

Abstract: There is low evidence for the possible association between obstructive sleep apnea-hypopnea syndrome (OSAHS) and periodontitis, necessitating further research. This study was aimed at investigating this association. For the in vitro study, 8-day-old Wistar rats… read more here.

Keywords: expression; group; pathway; txnip nlrp3 ... See more keywords

Activation of LRP1 Ameliorates Cerebral Ischemia/Reperfusion Injury and Cognitive Decline by Suppressing Neuroinflammation and Oxidative Stress through TXNIP/NLRP3 Signaling Pathway in Mice

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/8729398

Abstract: Cerebral ischemia/reperfusion (I/R) injury is a clinical event associated with high morbidity and mortality. Neuroinflammation plays a crucial role in the pathogenesis of I/R-induced brain injury and cognitive decline. Low-density lipoprotein receptor-related protein-1 (LRP1) can… read more here.

Keywords: lrp1; txnip; signaling pathway; nlrp3 signaling ... See more keywords

miR-17-5p Promotes Glucose Uptake of HTR8/SVneo Trophoblast Cells by Inhibiting TXNIP/NLRP3 Inflammasome Pathway

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recommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"

DOI: 10.2147/dmso.s385774

Abstract: Introduction Gestational diabetes mellitus (GDM) is one of the common metabolic disorders of pregnancy and results in poor pregnancy outcomes for both mother and fetus. MiR-17-5p is considered as the strongest predictor of metabolic syndrome… read more here.

Keywords: mir; txnip; txnip nlrp3; htr8 svneo ... See more keywords

miRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells

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recommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.00871

Abstract: The role and mechanism of pyroptosis in intervertebral disk (IVD) degeneration are unclear. MicroRNAs (miRNAs) regulate the viability and function of nucleus pulposus cells (NPCs) in IVDs and are related to pyroptosis. We performed microarray… read more here.

Keywords: pyroptosis; degeneration; ros generation; txnip nlrp3 ... See more keywords