Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin
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DOI: 10.1016/j.redox.2021.102184
Abstract: Anticancer drugs that target cellular antioxidant systems have recently attracted much attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer agent that targets the cytosolic and mitochondrial forms of the selenoprotein… read more here.
Keywords: thioredoxin reductase; comprehensive chemical; txnrd1 inhibitors; tri ... See more keywords