Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors.
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DOI: 10.1021/acs.jmedchem.2c01800
Abstract: Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and autoimmune diseases. Due to safety concerns of… read more here.
Keywords: kinase; tyk2 inhibitors; tyrosine kinase; therapeutic implications ... See more keywords
Selective TYK2 inhibitors as potential therapeutic agents: a patent review (2019–2021)
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DOI: 10.1080/13543776.2022.2026927
Abstract: ABSTRACT Introduction Tyrosine kinase 2 (TYK2) is a member of the JAK family class of kinases that is responsible for mediating the immune response to IL-12, IL-23, and IFNα. The therapeutic value of targeting this… read more here.
Keywords: review; inhibitors potential; selective tyk2; tyk2 ... See more keywords