Total synthesis of (R)-tylophorine by using an asymmetric hydrogenation of the allyl alcohol
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DOI: 10.1016/j.tetlet.2018.04.052
Abstract: Abstract An efficient synthesis of naturally occurring (R)-tylophorine is described. The alkaloid was prepared in seven steps from a known phenanthryl aldehyde with an overall yield of 14.2%. Asymmetric hydrogenation of an allyl alcohol was… read more here.
Keywords: allyl alcohol; asymmetric hydrogenation; tylophorine; hydrogenation allyl ... See more keywords
Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives
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DOI: 10.3389/fphar.2020.606097
Abstract: Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively. We tested both types of compounds against two types of… read more here.
Keywords: tylophorine based; potent broad; tylophorine; sars cov ... See more keywords