Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular Therapeutics"
DOI: 10.1155/cdr/1129181
Abstract: Background: Thymidine phosphorylase (TYMP) promotes platelet activation and thrombosis while suppressing vascular smooth muscle cell (VSMC) proliferation. Both processes are central to the development and progression of abdominal aortic aneurysms (AAAs). We hypothesize that TYMP… read more here.
Keywords: thymidine phosphorylase; activation vsmcs; activation; abdominal aortic ... See more keywords
Influence of repetitive diving in freshwater on pressure equalization and Eustachian tube function in recreational scuba divers.
Sign Up to like & getrecommendations! Published in 2017 at "Diving and hyperbaric medicine"
DOI: 10.28920/dhm47.4.223-227
Abstract: INTRODUCTION We investigated the effect of repetitive pressure exposure during freshwater dives on Eustachian tube function and the middle ear, assessed by the Eustachian tube function test (ETFT). METHODS This prospective observational cohort study included… read more here.
Keywords: eustachian tube; tube function; middle ear; tymp ... See more keywords
TYMP Variants Result in Late-Onset Mitochondrial Myopathy With Altered Muscle Mitochondrial DNA Homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.00860
Abstract: Biallelic TYMP variants result in the mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a juvenile-onset disorder with progressive course and fatal outcome. Milder late-onset (>40 years) form has been rarely described. Gene panel sequencing in a cohort of… read more here.
Keywords: late onset; muscle; tymp; tymp variants ... See more keywords