Advances in the TBAF-induced aldol-type addition of α-trialkylsilyl-α-diazoacetones: TIPS versus TES
Sign Up to like & getrecommendations! Published in 2017 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2016.12.005
Abstract: Abstract α-Triisopropylsilyl-α-diazoacetone (TIPS-diazoacetone) underwent high-yielding “diazo-side” Mukaiyama aldol-type addition with a range of aryl and alkyl aldehydes when subjected to stoichiometric amount of tetrabutylammonium fluoride at −16 °C, in Et2O. Robustness of the TIPS group makes… read more here.
Keywords: type addition; tips diazoacetone; aldol type; advances tbaf ... See more keywords
Stabilization of 4-phenylurazole by electrografting on a nano-fibrillated mesoporous carbon modified electrode. Reactivity of anchored triazolinedione groups against Michael-type addition at electrode/electrolyte interface
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DOI: 10.1016/j.electacta.2018.02.158
Abstract: Abstract Fabricartion of a redox-active electrode by modification of a glassy carbon electrode (GCE) with a unique ionic liquid derived fibrillated mesoporous carbon (IFMC) following the electrografting of 4-phenylurazole via electrochemical reduction of 4-(4-nitrophenyl)urazole in… read more here.
Keywords: michael type; carbon; fibrillated mesoporous; type addition ... See more keywords
Thiol-based michael-type addition. A systematic evaluation of its controlling factors
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DOI: 10.1016/j.tet.2020.131637
Abstract: Abstract This paper is about the factors controlling kinetics and product stability of this popular bioconjugation reaction. We demonstrate that a) thiol pKa, i.e. the amount of thiolates, is the only determinant of the reaction… read more here.
Keywords: type addition; addition systematic; michael type; reaction ... See more keywords
Mannich-type addition of cyclic 1,3-diketones to N-acyliminium ions: Access to aza-sugars.
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DOI: 10.2139/ssrn.4311169
Abstract: A novel three-component strategy has been developed for the synthesis of iminosugars in good to excellent yields. This is the first report on the Mannich type addition of cyclic 1,3-diketones to aza-acetal derived from hydroxy-γ-lactone… read more here.
Keywords: aza sugars; type addition; mannich type; addition cyclic ... See more keywords
Synthesis of 4-Imidazolidinones from Diamides and Ethynyl Benziodoxolones via Double Michael-Type Addition: Ethynyl Benziodoxolones as Electrophilic Ynol Synthons.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.26434/chemrxiv-2022-bb2bt
Abstract: The moiety of 4-imidazolidinone is an important structural motif in organic synthesis and medicinal chemistry. We present the synthesis of 4-imidazolidinones from various diamides with ethynyl benziodoxolones through double Michael-type addition, which is an unprecedented… read more here.
Keywords: diamides ethynyl; ethynyl benziodoxolones; type addition; double michael ... See more keywords