SN1-Type Alkylation of N-Heteroaromatics with Alcohols.
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DOI: 10.1021/acs.orglett.7b02294
Abstract: The organocatalytic alkylation of 2-methyl-N-heteroaromatics with alcohols has been achieved via SN1-type C(sp3)-H functionalization, providing a green and efficient synthesis of indole and ferrocene-functionalized N-heteroaromatics in high yields. read more here.
Keywords: heteroaromatics alcohols; sn1 type; alkylation heteroaromatics; type alkylation ... See more keywords
Photoredox-Mediated Minisci-type Alkylation of N-Heteroarenes with Alkanes with High Methylene Selectivity
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DOI: 10.1021/acscatal.8b04079
Abstract: We report a highly efficient and chemoselective Minisci-type alkylation reaction of N-heteroarenes with alkanes under the reagent control of a hypervalent iodine oxidant PFBI-OH. In addition to the high reactivity, PFBI-OH demonstrated a high steric… read more here.
Keywords: heteroarenes alkanes; minisci type; methylene; selectivity ... See more keywords
K2S2O8-Activated Friedel–Crafts Type Alkylation of Indoles with α-Amido Sulfones
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DOI: 10.1055/s-0036-1589073
Abstract: A K 2 S 2 O 8 -activated regioselective alkylation of α-amido sulfones at the C-3 position of indoles is reported. The protocol developed herein provides an alternative new strategy to the previous approach by… read more here.
Keywords: alkylation indoles; amido sulfones; crafts type; alkylation ... See more keywords