GSH as an A‐A Type Allosteric Activator of PKM2: Modulating Cancer Cell Homeostasis and Ferroptosis Susceptibility
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DOI: 10.1002/advs.202519368
Abstract: This study identifies glutathione (GSH) as an endogenous A‐A type allosteric activator of pyruvate kinase M2 (PKM2), stabilizing it in its active tetrameric form through binding at the A‐A interface. This PKM2‐GSH interaction links GSH… read more here.
Keywords: type allosteric; pkm2; allosteric activator; ferroptosis ... See more keywords