Oxidative stress caused by accumulation of misfolded Z-type alpha1-antitrypsin
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DOI: 10.1016/j.freeradbiomed.2018.04.237
Abstract: Accumulation of misfolded human Z-type alpha1-antitrypsin protein in the endoplasmic reticulum (ER) leads to persistent ER stress and subsequent cell death, leading to liver cirrhosis. When a Saccharomyces cerevisiae ORF-deletion library was screened for the… read more here.
Keywords: type alpha1; stress; accumulation misfolded; alpha1 antitrypsin ... See more keywords