Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104921
Abstract: l-Type amino acid transporter 1 (LAT1) is an interesting protein due to its peculiar expression profile. It can be utilized not only as a carrier for improved or targeted drug delivery, e.g., into the brain… read more here.
Keywords: amino acid; transporter lat1; type amino; acid transporter ... See more keywords
Structural properties for selective and efficient l‐type amino acid transporter 1 (LAT1) mediated cellular uptake
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.025
Abstract: Graphical abstract Figure. No Caption available. Abstract l‐Type amino acid transporter 1 (LAT1) is a sodium‐independent exchanger transporting large neural amino acids and several amino‐acid mimicking drugs across the cell membranes. LAT1 is highly expressed… read more here.
Keywords: amino acid; transporter lat1; type amino; acid transporter ... See more keywords
Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.01.024
Abstract: The L-type amino acid transporter 2 (LAT2) imports amino acids (AA) and also certain thyroid hormones (TH), e.g. 3,3'-T2 and T3, but not rT3 and T4. We utilized LAT2 mutations (Y130A, N133S, F242W) that increase… read more here.
Keywords: export; amino acid; type amino; acid transporter ... See more keywords
Involvement of l-type amino acid transporter 1 in the transport of gabapentin into human placental choriocarcinoma cells.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2016.11.002
Abstract: Gabapentin (GBP) is a widely used antiepileptic drug, with potential for use in the treatment of epilepsy in pregnant women. Although studies have examined GBP transport mechanisms across the blood-brain barrier, kidney, and intestine, the… read more here.
Keywords: type amino; transport; human placental; placental choriocarcinoma ... See more keywords
L-type Amino Acid Transporter 1 Utilizing Ferulic Acid Derivatives Show Increased Drug Delivery in the Mouse Pancreas Along with Decreased Lipid Peroxidation and Prostaglandin Production
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00328
Abstract: Oxidative stress and pathological changes of Alzheimer’s disease (AD) overlap with metabolic diseases, such as diabetes mellitus (DM). Therefore, tackling oxidative stress with antioxidants is a compelling drug target against multiple chronic diseases simultaneously. Ferulic… read more here.
Keywords: type amino; mouse; drug; delivery ... See more keywords
A Candidate Bacterial-Type Amino Acid Decarboxylase Is Essential for Male Gamete Exflagellation and Mosquito Transmission of the Malaria Parasite
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00167-23
Abstract: A frequent side effect of chemotherapy against malaria parasite blood infections is a dramatic induction of the sexual blood stages, thereby enhancing the risk of future malaria transmissions. The polyamine biosynthesis pathway has been suggested… read more here.
Keywords: malaria parasite; bacterial type; type amino; transmission ... See more keywords
Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1034964
Abstract: A prodrug approach is a powerful method to temporarily change the physicochemical and thus, pharmacokinetic properties of drugs. However, in site-selective targeted prodrug delivery, tissue or cell-specific bioconverting enzyme is needed to be utilized to… read more here.
Keywords: amide prodrugs; type amino; brain; acid transporter ... See more keywords
Therapeutic Potential for Intractable Asthma by Targeting L-Type Amino Acid Transporter 1
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040553
Abstract: Bronchial asthma is a chronic disease characterized by airway inflammation, obstruction, and hyperresponsiveness. CD4+ T cells, particularly T helper (Th) 2 cells, and their specific cytokines are important mediators in asthma pathogenesis. However, it has… read more here.
Keywords: type amino; asthma; acid transporter; amino acid ... See more keywords
The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102428
Abstract: Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are… read more here.
Keywords: amino acid; type amino; acid transporter; lat1 ... See more keywords
Influence of the Type of Amino Acid on the Permeability and Properties of Ibuprofenates of Isopropyl Amino Acid Esters
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084158
Abstract: Modifications of (RS)-2-[4-(2-methylpropyl)phenyl] propanoic acid with amino acid isopropyl esters were synthesised using different methods via a common intermediate. The main reaction was the esterification of the carboxyl group of amino acids with isopropanol and… read more here.
Keywords: influence type; type amino; amino acid; permeability ... See more keywords
Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158446
Abstract: Sesamol is a compound reported to have anti-melanogenesis and anti-melanoma actions. Sesamol, however, has low intracellular drug concentration and fast excretion, which can limit its benefits in the clinic. To overcome this drawback and increase… read more here.
Keywords: sesamol; sesamol prodrug; melanoma; type amino ... See more keywords