Mutations in the β-amyloid precursor protein in familial Alzheimer’s disease increase Aβ oligomer production in cellular models
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DOI: 10.1016/j.heliyon.2018.e00511
Abstract: Soluble oligomers of amyloid-β (Aβ) peptides (AβOs) contribute to neurotoxicity in Alzheimer’s disease (AD). However, it currently remains unknown whether an increase in AβOs is the common phenotype in cellular and animal models. Furthermore, it… read more here.
Keywords: alzheimer disease; type app; precursor protein; app ... See more keywords