Phosphorylation states greatly regulate the activity and gating properties of Cav3.1 T‐type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30920
Abstract: Cav3.1 T‐type Ca2+ channels play pivotal roles in neuronal low‐threshold spikes, visceral pain, and pacemaker activity. Phosphorylation has been reported to potently regulate the activity and gating properties of Cav3.1 channels. However, systematic identification of… read more here.
Keywords: cav3 type; type ca2; activity; ca2 channels ... See more keywords
Liquiritigenin protects against myocardial ischemic by inhibiting oxidative stress, apoptosis, and L‐type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7528
Abstract: Liquiritigenin (Lq) offers cytoprotective effects against various cardiac injuries, but its beneficial effects on myocardial ischemic (MI) injury and the related mechanisms remain unclear. In the in vivo study, an animal model of MI was… read more here.
Keywords: mol; myocardial ischemic; apoptosis; type ca2 ... See more keywords
Intracellular emetic signaling evoked by the L‐type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva)
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.06.035
Abstract: ABSTRACT Ca2+ plays a major role in maintaining cellular homeostasis and regulates processes including apoptotic cell death and side‐effects of cancer chemotherapy including vomiting. Currently we explored the emetic mechanisms of FPL64176, an L‐type Ca2+… read more here.
Keywords: ca2 channel; type ca2; ca2; fpl64176 induced ... See more keywords
Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2019.05.006
Abstract: Temporal lobe epilepsy (TLE) is a form of adult epilepsy involving the entorhinal cortex (EC). Layer II neurons of the medial EC (mEC) are spared and become hyperexcitable in TLE. Studies have suggested a role… read more here.
Keywords: mec layer; type ca2; type; neuronal hyperexcitability ... See more keywords
Alzheimer's disease therapeutic candidate SAK3 is an enhancer of T-type calcium channels.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.11.014
Abstract: Low-threshold Ca2+ spikes are mediated by T-type Ca2+ channels, which have electrophysiological properties of fast inactivation and slow deactivation kinetics. A low membrane potential of approximately -60 mV is sufficient to trigger channel opening. We recently introduced… read more here.
Keywords: alzheimer disease; channel; ca2; type ca2 ... See more keywords
Vasodilatory effect of formaldehyde via the NO/cGMP pathway and the regulation of expression of KATP, BKCa and L-type Ca2+ channels.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.04.006
Abstract: Formaldehyde (FA), a well-known toxic gas molecule similar to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), is widely produced endogenously via numerous biochemical pathways, and has a number of physiological roles in… read more here.
Keywords: cgmp pathway; expression; type ca2; regulation ... See more keywords
AKAP5 complex facilitates purinergic modulation of vascular L-type Ca2+ channel CaV1.2
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18947-y
Abstract: The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unclear. Here, we… read more here.
Keywords: ca2 channel; cav1; type ca2;
Optical control of L-type Ca2+ channels using a diltiazem photoswitch
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.1038/s41589-018-0090-8
Abstract: L-type Ca2+ channels (LTCCs) play a crucial role in excitation–contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem,… read more here.
Keywords: ca2 channels; optical control; type ca2; ca2 ... See more keywords
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52194-6
Abstract: Cav3 / T-type Ca2+ channels are dynamically regulated by intracellular Ca2+ ions, which inhibit Cav3 availability. Here, we demonstrate that this inhibition becomes irreversible in the presence of non-hydrolysable ATP analogs, resulting in a strong… read more here.
Keywords: mechanism; cav3; type ca2; ca2 ... See more keywords
New aspects in cardiac L-type Ca2+ channel regulation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20190229
Abstract: Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization.… read more here.
Keywords: channel; ca2; new aspects; aspects cardiac ... See more keywords
T-type Ca2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14788
Abstract: BACKGROUND AND PURPOSE Mibefradil (Mib), a T-type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on… read more here.
Keywords: channel blocker; mib; channel; ca2 channel ... See more keywords