Structure and genome editing of type I-B CRISPR-Cas
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48598-2
Abstract: Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prokaryotes. Their ability to cause long fragment deletions… read more here.
Keywords: crispr cas; type; type cascade; type crispr ... See more keywords
A transferrable and integrative type I-F Cascade for heterologous genome editing and transcription modulation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab521
Abstract: Abstract The Class 1 type I CRISPR–Cas systems represent the most abundant and diverse CRISPR systems in nature. However, their applications for generic genome editing have been hindered due to difficulties of introducing the class-specific,… read more here.
Keywords: genome editing; type cascade; cascade heterologous; cascade ... See more keywords