Type II cGMP-dependent protein kinase phosphorylates EGFR at threonine 669 and thereby inhibits its activation.
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DOI: 10.1016/j.bbrc.2019.07.126
Abstract: Our previous study demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF) induced tyrosine phosphorylation/activation of the EGF receptor (EGFR). This paper was designed to investigate the mechanism of the… read more here.
Keywords: egfr; kinase; type cgmp; pkg ... See more keywords