Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves’ disease influencing the therapeutic efficacy
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DOI: 10.1007/s10238-018-00542-7
Abstract: Graves’ disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves’ hyperthyroidism is characterized by T3 dominance due to the conversion of T4… read more here.
Keywords: peptide antibodies; type deiodinase; antithyroid drugs; dio2 ... See more keywords
Early developmental disruption of type 2 deiodinase pathway in mouse skeletal muscle does not impair muscle function
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DOI: 10.1089/thy.2016.0392
Abstract: Background: Myogenesis is positively regulated by thyroid hormone (triiodothyronine [T3]), which is amplified by the type 2 deiodinase (D2) activation of thyroxine to T3. Global inactivation of the Dio2 gene impairs skeletal muscle (SKM) differentiation… read more here.
Keywords: skeletal muscle; disruption; muscle; early developmental ... See more keywords
SAT-552 Oxidative Stress Induces Type 3 Deiodinase on Multiple Tissues in Disease: Implications to Nonthyroidal Illness Syndrome Pathophysiology
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DOI: 10.1210/js.2019-sat-552
Abstract: Abstract Imbalances in the redox status are involved in type 3 deiodinase (D3) induction in the non-thyroidal illness syndrome (NTIS). The mechanisms responsible for D3 dysfunction under systemic redox alterations in disease are poorly understood.… read more here.
Keywords: illness syndrome; type deiodinase; multiple tissues; induction ... See more keywords
Deiodinases in thyroid tumorigenesis
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DOI: 10.1530/erc-23-0015
Abstract: The three deiodinase selenoenzymes are key regulators of intracellular thyroid hormone (TH) levels. The two TH-activating deiodinases (type 1 deiodinase and type 2 deiodinase (D2)) are normally expressed in follicular thyroid cells and contribute to… read more here.
Keywords: thyroid cancers; type deiodinase; thyroid tumorigenesis; deiodinase ... See more keywords
Type 2 deiodinase is expressed in anaplastic thyroid carcinoma and its inhibition causes cell senescence
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DOI: 10.1530/erc-23-0016
Abstract: Anaplastic thyroid cancer (ATC) is a rare thyroid tumor that frequently originates from the dedifferentiation of a well-differentiated papillary or follicular thyroid cancer. Type 2 deiodinase (D2), responsible for the activation of the thyroid hormone… read more here.
Keywords: cell; type deiodinase; thyroid; thyroid cancer ... See more keywords
Relationship among Low T3 Levels, Type 3 Deiodinase, Oxidative Stress, and Mortality in Sepsis and Septic Shock: Defining Patient Outcomes
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DOI: 10.3390/ijms24043935
Abstract: Low T3 syndrome occurs frequently in patients with sepsis. Type 3 deiodinase (DIO3) is present in immune cells, but there is no description of its presence in patients with sepsis. Here, we aimed to determine… read more here.
Keywords: type deiodinase; low levels; sepsis septic; septic shock ... See more keywords