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Published in 2018 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-018-00542-7
Abstract: Graves’ disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves’ hyperthyroidism is characterized by T3 dominance due to the conversion of T4…
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Keywords:
peptide antibodies;
type deiodinase;
antithyroid drugs;
dio2 ... See more keywords
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Published in 2017 at "Thyroid"
DOI: 10.1089/thy.2016.0392
Abstract: Background: Myogenesis is positively regulated by thyroid hormone (triiodothyronine [T3]), which is amplified by the type 2 deiodinase (D2) activation of thyroxine to T3. Global inactivation of the Dio2 gene impairs skeletal muscle (SKM) differentiation…
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Keywords:
skeletal muscle;
disruption;
muscle;
early developmental ... See more keywords
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Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-552
Abstract: Abstract Imbalances in the redox status are involved in type 3 deiodinase (D3) induction in the non-thyroidal illness syndrome (NTIS). The mechanisms responsible for D3 dysfunction under systemic redox alterations in disease are poorly understood.…
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Keywords:
illness syndrome;
type deiodinase;
multiple tissues;
induction ... See more keywords
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Published in 2023 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-23-0015
Abstract: The three deiodinase selenoenzymes are key regulators of intracellular thyroid hormone (TH) levels. The two TH-activating deiodinases (type 1 deiodinase and type 2 deiodinase (D2)) are normally expressed in follicular thyroid cells and contribute to…
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Keywords:
thyroid cancers;
type deiodinase;
thyroid tumorigenesis;
deiodinase ... See more keywords
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Published in 2023 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-23-0016
Abstract: Anaplastic thyroid cancer (ATC) is a rare thyroid tumor that frequently originates from the dedifferentiation of a well-differentiated papillary or follicular thyroid cancer. Type 2 deiodinase (D2), responsible for the activation of the thyroid hormone…
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Keywords:
cell;
type deiodinase;
thyroid;
thyroid cancer ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043935
Abstract: Low T3 syndrome occurs frequently in patients with sepsis. Type 3 deiodinase (DIO3) is present in immune cells, but there is no description of its presence in patients with sepsis. Here, we aimed to determine…
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Keywords:
type deiodinase;
low levels;
sepsis septic;
septic shock ... See more keywords