N‐Dihydrogalactochitosan Drives Conventional and Alternative Activations of STING to Synergize Type I IFN and IL‐1β Productions for Antitumor Immunity.
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DOI: 10.1002/adfm.202410079
Abstract: N‐dihydrogalactochitosan (GC) is an immune stimulant/adjuvant. Synthesized from chitosan and galactose, GC is a new chemical entity that significantly enhances the immune‐stimulating properties of its parental material, chitosan, making it a promising therapeutic agent. When… read more here.
Keywords: dihydrogalactochitosan drives; conventional alternative; type; type ifn ... See more keywords
Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
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DOI: 10.1002/eji.202048793
Abstract: Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling pathway, which also governs… read more here.
Keywords: response; cellular responses; viral infections; ifns ... See more keywords
Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β
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DOI: 10.1007/s10875-021-01068-6
Abstract: Since December 2019, over 150 million individuals have been infected with SARS-CoV-2 globally. While most cases (>95%) are asymptomatic or mild, a small proportion develop moderate, severe, or critical COVID-19 pneumonia requiring hospitalization, at times… read more here.
Keywords: type ifn; sars cov; ifn immunity; ifn ... See more keywords
Evaluation of Genetic or Cellular Impairments in Type I IFN Immunity in a Cohort of Young Adults with Critical COVID-19
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DOI: 10.1007/s10875-023-01641-1
Abstract: Several genetic and immunological risk factors for severe COVID-19 have been identified, with monogenic conditions relating to 13 genes of type I interferon (IFN) immunity proposed to explain 4.8% of critical cases. However, previous cohorts… read more here.
Keywords: critical covid; covid; ifn immunity; young adults ... See more keywords
Type I interferon in the pathogenesis of systemic lupus erythematosus.
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DOI: 10.1016/j.coi.2020.10.014
Abstract: Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as… read more here.
Keywords: type interferon; systemic lupus; lupus erythematosus; type ifn ... See more keywords
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis.
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DOI: 10.1016/j.cyto.2019.05.018
Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease which affects multiple organs. The type I interferon (IFN) gene signature and circulating autoantibodies are hallmarks of SLE. Plasmacytoid dendritic cells (pDCs) are considered the main… read more here.
Keywords: immune; irf5; sle; type ifn ... See more keywords
Intronless and intron‐containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates
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DOI: 10.1016/j.dci.2016.10.007
Abstract: ABSTRACT Type I IFNs are considered to be the core IFN species in vertebrates because of their predominant antiviral effects. But, a puzzling question remains to be answered, as to how intronless type I IFN… read more here.
Keywords: ifn genes; ifns; type ifn; type ifns ... See more keywords
Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway
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DOI: 10.1016/j.ebiom.2017.07.016
Abstract: Cyclic di-nucleotides (CDN) are potent stimulators of innate and adaptive immune responses. Cyclic di-AMP (CDA) is a promising adjuvant that generates humoral and cellular immunity. The strong STING-dependent stimulation of type I IFN represents a… read more here.
Keywords: ifn; cross presentation; type ifn; ifn tnf ... See more keywords
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production
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DOI: 10.1016/j.ebiom.2018.11.062
Abstract: Background Type I IFN-based therapies against solid malignancies have yielded only limited success. How IFN affects tumor-associated macrophage (TAM) compartment to impact the therapeutic outcomes are not well understood. Methods The effect of an IFN-inducer… read more here.
Keywords: type ifn; csf signaling; ifn; tumor ... See more keywords
Recombinant MUC1-MBP fusion protein vaccine combined with CpG2006 induces antigen-specific CTL responses through cDC1-mediated cross-priming mainly regulated by type I IFN signaling in mice.
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DOI: 10.1016/j.imlet.2022.04.002
Abstract: In this study, we explored the initiation and regulation mechanism of antigen-specific CTL responses induced by a novel cancer vaccine containing recombinant human mucin1-maltose-binding protein fusion protein (MUC1-MBP) and CpG2006. First, DC subsets were analyzed… read more here.
Keywords: specific ctl; ifn signaling; type ifn; ctl responses ... See more keywords
Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses
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DOI: 10.1016/j.isci.2021.102477
Abstract: Type I interferons (IFNs) are our first line of defence against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of… read more here.
Keywords: type ifn; activation; type; sars cov ... See more keywords