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Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048793
Abstract: Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling pathway, which also governs…
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Keywords:
response;
cellular responses;
viral infections;
ifns ... See more keywords
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Published in 2021 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-021-01068-6
Abstract: Since December 2019, over 150 million individuals have been infected with SARS-CoV-2 globally. While most cases (>95%) are asymptomatic or mild, a small proportion develop moderate, severe, or critical COVID-19 pneumonia requiring hospitalization, at times…
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Keywords:
type ifn;
sars cov;
ifn immunity;
ifn ... See more keywords
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Published in 2020 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2020.10.014
Abstract: Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as…
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Keywords:
type interferon;
systemic lupus;
lupus erythematosus;
type ifn ... See more keywords
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Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.05.018
Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease which affects multiple organs. The type I interferon (IFN) gene signature and circulating autoantibodies are hallmarks of SLE. Plasmacytoid dendritic cells (pDCs) are considered the main…
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Keywords:
immune;
irf5;
sle;
type ifn ... See more keywords
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Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.10.007
Abstract: ABSTRACT Type I IFNs are considered to be the core IFN species in vertebrates because of their predominant antiviral effects. But, a puzzling question remains to be answered, as to how intronless type I IFN…
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Keywords:
ifn genes;
ifns;
type ifn;
type ifns ... See more keywords
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Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.07.016
Abstract: Cyclic di-nucleotides (CDN) are potent stimulators of innate and adaptive immune responses. Cyclic di-AMP (CDA) is a promising adjuvant that generates humoral and cellular immunity. The strong STING-dependent stimulation of type I IFN represents a…
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Keywords:
ifn;
cross presentation;
type ifn;
ifn tnf ... See more keywords
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Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.11.062
Abstract: Background Type I IFN-based therapies against solid malignancies have yielded only limited success. How IFN affects tumor-associated macrophage (TAM) compartment to impact the therapeutic outcomes are not well understood. Methods The effect of an IFN-inducer…
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Keywords:
type ifn;
csf signaling;
ifn;
tumor ... See more keywords
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Published in 2022 at "Immunology letters"
DOI: 10.1016/j.imlet.2022.04.002
Abstract: In this study, we explored the initiation and regulation mechanism of antigen-specific CTL responses induced by a novel cancer vaccine containing recombinant human mucin1-maltose-binding protein fusion protein (MUC1-MBP) and CpG2006. First, DC subsets were analyzed…
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Keywords:
specific ctl;
ifn signaling;
type ifn;
ctl responses ... See more keywords
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Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102477
Abstract: Type I interferons (IFNs) are our first line of defence against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of…
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Keywords:
type ifn;
activation;
type;
sars cov ... See more keywords
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Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.06.002
Abstract: Ultraviolet (UV) light is a known trigger of skin and possibly systemic inflammation in systemic lupus erythematosus (SLE) patients. Although type I interferons (IFN) are upregulated in SLE skin after UV exposure, the mechanisms to…
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Keywords:
lupus prone;
type ifn;
mice;
prone mice ... See more keywords
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Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102525
Abstract: Interferon-β has therapeutic efficacy in Multiple Sclerosis by reducing disease exacerbations and delaying relapses. Previous studies have suggested that the effects of type I IFN in Experimental Autoimmune Encephalomyelitis (EAE) in mice were targeted to…
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Keywords:
type ifn;
chemokine production;
production;
cko mice ... See more keywords