Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048793
Abstract: Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling pathway, which also governs… read more here.
Keywords: response; cellular responses; viral infections; ifns ... See more keywords
Naturally produced type I IFNs enhance human myeloid dendritic cell maturation and IL-12p70 production and mediate elevated effector functions in innate and adaptive immune cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2204-2
Abstract: There has recently been a paradigm shift in the field of dendritic cell (DC)-based immunotherapy, where several clinical studies have confirmed the feasibility and advantageousness of using directly isolated human blood-derived DCs over in vitro… read more here.
Keywords: production; 12p70 production; type ifns; maturation ... See more keywords
Plasmacytoid dendritic cells and type I interferons in flares of systemic lupus erythematosus triggered by COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04825-3
Abstract: We recently read with interest the article entitled “Can the SARS-CoV-2 infection trigger systemic lupus erythematosus? A case-based review” by Gracia-Ramos et al. [1]. The authors reviewed emerging cases of SARS-CoV-2 infection either flaring-up previously… read more here.
Keywords: sle; infection; type ifns; type ... See more keywords
Type I interferons and SARS-CoV-2: from cells to organisms
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Immunology"
DOI: 10.1016/j.coi.2022.01.003
Abstract: Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and… read more here.
Keywords: interferons sars; sars cov; type ifns; type interferons ... See more keywords
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.05.018
Abstract: Systemic lupus erythematosus (SLE) is a complex autoimmune disease which affects multiple organs. The type I interferon (IFN) gene signature and circulating autoantibodies are hallmarks of SLE. Plasmacytoid dendritic cells (pDCs) are considered the main… read more here.
Keywords: immune; irf5; sle; type ifn ... See more keywords
Intronless and intron‐containing type I IFN genes coexist in amphibian Xenopus tropicalis: Insights into the origin and evolution of type I IFNs in vertebrates
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.10.007
Abstract: ABSTRACT Type I IFNs are considered to be the core IFN species in vertebrates because of their predominant antiviral effects. But, a puzzling question remains to be answered, as to how intronless type I IFN… read more here.
Keywords: ifn genes; ifns; type ifn; type ifns ... See more keywords
Myxovirus resistance (Mx) gene and its differential expression regulated by three type I and two type II IFNs in mandarin fish, Siniperca chuatsi.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2019.103604
Abstract: Interferons (IFNs) can induce the expression of IFN-stimulated genes (ISGs), such as myxovirus resistance (Mx) protein, to inhibit virus replication. In this study, the expression of Mx gene in mandarin fish, and the IFN-sensitive response… read more here.
Keywords: ifn; type ifns; expression; type ... See more keywords
Glycosylation tips the scales: Novel insights into the dual role of type-I interferons in treated HIV infection
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103003
Abstract: It is well known that the release of type-I interferons, IFNa and IFNb in response to infection is a “tightrope walk” since they may act as either friend or foe. On one hand, type-I IFNs… read more here.
Keywords: hiv; infection; type ifns; glycosylation ... See more keywords
Lambda interferons in immunity and autoimmunity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102319
Abstract: Type I IFNs are well known players in immunity and autoimmunity. They induce potent innate and adaptive immune responses essential for mediating host defenses against viral and bacterial infections but also driving inflammation during chronic… read more here.
Keywords: immunity autoimmunity; lambda interferons; ifns; type ifns ... See more keywords
Type I interferons in the pathogenesis and treatment of canine diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.08.006
Abstract: Type I interferons (IFNs) such as IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω represent cytokines, which are deeply involved in the regulation and activation of innate and adaptive immune responses. They possess strong antiviral, antiproliferative, and… read more here.
Keywords: canine; canine diseases; type ifns; type ... See more keywords
Anti-chicken type I IFN countermeasures by Major Avian RNA Viruses.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198061
Abstract: Chicken type I interferons (type I IFNs) are key antiviral players of the chicken innate immune system and are considered potent antiviral agents against avian viral pathogens. Chicken type I IFNs are divided into three… read more here.
Keywords: type; type ifns; avian rna; chicken type ... See more keywords