Immunoregulation of asthma by type2 cytokine therapies - treatments for all ages?
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202249919
Abstract: Asthma is classically considered to be a disease of type 2 immune dysfunction, since many patients exhibit the consequences of excess secretion of cytokines such as IL-4, IL-5 and IL-13 concomitant with inflammation typified by… read more here.
Keywords: immunoregulation asthma; type2 cytokine; cytokine therapies; therapies treatments ... See more keywords
Assessing the Mouse Intestinal Microbiota in Settings of Type-2 Immune Responses.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7896-0_26
Abstract: The microbial communities that reside within the mammalian host play important roles in the development of a robust host immune system. With the advent of sequencing technology and barcoding strategy of the bacterial 16S ribosomal… read more here.
Keywords: intestinal microbiota; type immune; settings type; assessing mouse ... See more keywords
A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.02.046
Abstract: The central pathogen-immune interface in tuberculosis is the granuloma, a complex host immune structure that dictates infection trajectory and physiology. Granuloma macrophages undergo a dramatic transition in which entire epithelial modules are induced and define… read more here.
Keywords: immune; type immune; epithelialization; granuloma formation ... See more keywords
Warifteine and methylwarifteine inhibited the type 2 immune response on combined allergic rhinitis and asthma syndrome (CARAS) experimental model through NF-кB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106616
Abstract: CARAS is an airway inflammation of allergic individuals, with a type 2 immune response. The pharmacotherapy is based on drugs with relevant side effects. Thus, the goal of this study evaluated the alkaloids warifteine (War)… read more here.
Keywords: methylwarifteine; experimental model; caras experimental; type immune ... See more keywords
Early Events Triggering the Initiation of a Type 2 Immune Response.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.11.006
Abstract: Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer,… read more here.
Keywords: initiation; immune responses; type immune; type ... See more keywords
Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.10.001
Abstract: BACKGROUND Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood… read more here.
Keywords: immunity; type immune; type immunity; immune response ... See more keywords
Relation between lower respiratory tract microbiota and type of immune response against tuberculosis.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.04.054
Abstract: In this study, the interaction between the microbiota of the lower respiratory tract and the type of immune response against Mycobacterium tuberculosis were studied. Bronchoalveolar lavage (BAL) samples of 10 tuberculosis (TB) patients and 5… read more here.
Keywords: microbiota; response; type immune; tuberculosis ... See more keywords
Aging impairs type 2 immune responses to nematodes associated with reduced gut microbiota responsiveness
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-16730-x
Abstract: Gastrointestinal nematode infections elicit robust type 2 immune responses that facilitate rapid parasite expulsion. Our previous studies demonstrated that 18-month-old mice exhibit both impaired nematode clearance and reduced type 2-cytokine production, suggesting that aging diminishes… read more here.
Keywords: microbiota; type immune; reduced gut; immune responses ... See more keywords
Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.01.016
Abstract: BACKGROUND & AIMS There is controversy regarding the role of the type 2 immune response in the pathogenesis of ulcerative colitis (UC)-few data are available from treatment-naive patients. We investigated whether genes associated with a… read more here.
Keywords: response; type immune; expression; immune response ... See more keywords
Dysfunction of type 1 and type 2 immune cells: a lesson from exhausted-like ILC2s and their activation-induced cell death
Sign Up to like & getrecommendations! Published in 2024 at "International Immunology"
DOI: 10.1093/intimm/dxae032
Abstract: Abstract The concept of immune cell exhaustion/dysfunction has developed mainly to understand impaired type 1 immune responses, especially by CD8 T-cells against tumors or virus-infected cells, and has been applied to other lymphocytes. Natural killer… read more here.
Keywords: type; activation; dysfunction; cell ... See more keywords
Differential requirement of TIR enzymatic activities in TIR-type immune receptor SNC1-mediated immunity
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac452
Abstract: Arabidopsis thaliana TIR-type immune receptor SNC1 (Suppressor of npr1-1, constitutive 1) requires NADase, but not the 2′,3′-cAMP/cGMP synthetase activity to trigger in planta immune responses. read more here.
Keywords: receptor snc1; type immune; immune receptor; immune ... See more keywords