Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.02.006
Abstract: &NA; Inflammatory bowel disease is a chronic, relapsing condition with two subtypes, Crohn's disease (CD) and ulcerative colitis (UC). Genome‐wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding affinity of… read more here.
Keywords: immunity; inflammation; type immunity; anti commensal ... See more keywords
Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1/type 2 immune response.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.10.001
Abstract: BACKGROUND Both human and mouse allergic contact dermatitis (ACD) frequently demonstrates a combined type 1 and type 2 immune response. However, the relative importance of type 2 immunity in this setting has been incompletely understood… read more here.
Keywords: immunity; type immune; type immunity; immune response ... See more keywords
Type 2 immunity in tissue repair and fibrosis
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DOI: 10.1038/nri.2017.90
Abstract: Type 2 immunity is characterized by the production of IL-4, IL-5, IL-9 and IL-13, and this immune response is commonly observed in tissues during allergic inflammation or infection with helminth parasites. However, many of the… read more here.
Keywords: fibrosis; repair; type immunity; tissue ... See more keywords
Type 2 immunity in allergic diseases
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-025-01261-2
Abstract: Significant advancements have been made in understanding the cellular and molecular mechanisms of type 2 immunity in allergic diseases such as asthma, allergic rhinitis, chronic rhinosinusitis, eosinophilic esophagitis (EoE), food and drug allergies, and atopic… read more here.
Keywords: type immunity; immunity allergic; allergic diseases; immunity ... See more keywords
TGF-β suppresses type 2 immunity to cancer
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DOI: 10.1038/s41586-020-2836-1
Abstract: The immune system uses two distinct defence strategies against infections: microbe-directed pathogen destruction characterized by type 1 immunity 1 , and host-directed pathogen containment exemplified by type 2 immunity in induction of tissue repair 2… read more here.
Keywords: tgf suppresses; tissue; type immunity; cancer cell ... See more keywords
A dual role of microbiota type 17 immunity in tissue repair and pain
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12630
Abstract: An extraordinary recent study by Enamorado et al . 1 has, for the first time, demonstrated that immunity to the microbiota enhances repair of sensory nerves and epithelial tissues within the skin. Colonization of the… read more here.
Keywords: repair; immunity; type immunity; role microbiota ... See more keywords
Updates on T helper type 17 immunity in respiratory disease
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1111/imm.13006
Abstract: Interleukin‐17 (IL‐17)‐producing cells play a critical role in mucosal immunity including the respiratory tract. This review will highlight recent advances in our understanding of these cells in mucosal immunity in the lung as well as… read more here.
Keywords: immunity; immunity respiratory; type immunity; updates helper ... See more keywords
Comment on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”
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DOI: 10.1126/science.abi5459
Abstract: Description Break et al. (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of AIRE and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and… read more here.
Keywords: aberrant type; comment aberrant; drives susceptibility; immunity drives ... See more keywords
Response to Comments on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections”
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abi8835
Abstract: Description Puel and Casanova and Kisand et al. challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence for causation is difficult to obtain in… read more here.
Keywords: response comments; aberrant type; immunity drives; type immunity ... See more keywords
Emerging Paradigms in Type 2 Immunity.
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DOI: 10.1146/annurev-immunol-101320-030339
Abstract: A principal purpose of type 2 immunity was thought to be defense against large parasites, but it also functions in the restoration of homeostasis, such as toxin clearance following snake bites. In other cases, like… read more here.
Keywords: paradigms type; type immunity; emerging paradigms; type ... See more keywords
Natural antibodies drive type 2 immunity in response to damage-associated molecular patterns
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DOI: 10.1172/jci.insight.177230
Abstract: Allergic airway disease (AAD) is an example of type 2 inflammation that leads to chronic airway eosinophilia controlled by CD4 Th2 cells. Inflammation is reinforced by mast cells and basophils armed with allergen-specific IgE made… read more here.
Keywords: molecular patterns; immunity; damage; natural antibodies ... See more keywords