Early Steps in C-Type Inactivation of the hERG Potassium Channel
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c01028
Abstract: Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of… read more here.
Keywords: potassium; type inactivation; selectivity filter; inactivation ... See more keywords
Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel
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DOI: 10.1126/sciadv.abm8804
Abstract: C-type inactivation is a process by which ion flux through a voltage-gated K+ (Kv) channel is regulated at the selectivity filter. While prior studies have indicated that C-type inactivation involves structural changes at the selectivity… read more here.
Keywords: voltage gated; gated channel; type inactivation; selectivity filter ... See more keywords
Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.924289
Abstract: Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of “gates” to regulate ion flow through the channels. An important gating mechanism, C-type inactivation, limits ion flow by… read more here.
Keywords: inactivation channels; underlying type; human kv1; mechanisms underlying ... See more keywords