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   Articles with "type inactivation" as a keyword



Early Steps in C-Type Inactivation of the hERG Potassium Channel

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recommendations! Published in 2022 at "Journal of Chemical Information and Modeling"

DOI: 10.1021/acs.jcim.2c01028

Abstract: Fast C-type inactivation confers distinctive functional properties to the hERG potassium channel, and its association to inherited and acquired cardiac arrythmias makes the study of the inactivation mechanism of hERG at the atomic detail of… read more here.

Keywords: potassium; type inactivation; selectivity filter; inactivation ... See more keywords

C-type inactivation and proton modulation mechanisms of the TASK3 channel

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2320345121

Abstract: Significance Investigations on the C-type gating of multiple potassium channels have revealed a consistent structural mechanism that deviations in the selectivity filter impair the coordination of potassium ions, in turn inactivating the channel. Given that… read more here.

Keywords: proton; task3 channel; inactivation proton; type inactivation ... See more keywords

Structural basis for C-type inactivation in a Shaker family voltage-gated K+ channel

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.abm8804

Abstract: C-type inactivation is a process by which ion flux through a voltage-gated K+ (Kv) channel is regulated at the selectivity filter. While prior studies have indicated that C-type inactivation involves structural changes at the selectivity… read more here.

Keywords: voltage gated; gated channel; type inactivation; selectivity filter ... See more keywords

Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.924289

Abstract: Voltage-gated potassium (Kv) channels modulate the function of electrically-excitable and non-excitable cells by using several types of “gates” to regulate ion flow through the channels. An important gating mechanism, C-type inactivation, limits ion flow by… read more here.

Keywords: inactivation channels; underlying type; human kv1; mechanisms underlying ... See more keywords

Isoleucine gate blocks K+ conduction in C-type inactivation

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recommendations! Published in 2024 at "eLife"

DOI: 10.7554/elife.97696

Abstract: Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter… read more here.

Keywords: filter; kv1 kv2; type; type inactivation ... See more keywords