Organoid Cultures for Assessing Intestinal Epithelial Differentiation and Function in Response to Type-2 Inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7896-0_29
Abstract: During helminth infection of the gastrointestinal tract, a complex Type-2 inflammatory response involving immunological and mucosal components is mounted to clear the infection and reestablish a physiologically normal state. This response is characterized by the… read more here.
Keywords: response; type inflammation; organoid cultures; inflammation ... See more keywords
Mucociliary clearance differs in mild asthma by levels of Type-2 inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Chest"
DOI: 10.1016/j.chest.2021.05.013
Abstract: BACKGROUND While mucus plugging is a well reported feature of asthma, it is unknown whether asthma and type-2 inflammation affect mucociliary clearance (MCC). RESEARCH QUESTION Does type 2 inflammation influence mucus clearance rates in mild… read more here.
Keywords: mcc; clearance differs; type inflammation; mucociliary clearance ... See more keywords
Increased type 2 inflammation post rhinovirus infection in patients with moderate asthma.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.154857
Abstract: Rhinovirus (RV) infections are a major cause of exacerbations in patients with asthma. Experimental RV challenges can provide insight into the pathophysiology of viral exacerbations. Previous reports, investigating mild or moderate asthma patients, have shown… read more here.
Keywords: moderate asthma; asthma patients; type inflammation; infection ... See more keywords
The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal Immunology"
DOI: 10.1038/mi.2016.74
Abstract: Non-invasive mucosal sampling (nasosorption and nasal curettage) was used following nasal allergen challenge with grass pollen in subjects with allergic rhinitis, in order to define the molecular basis of the late allergic reaction (LAR). It… read more here.
Keywords: pollen involves; grass; type inflammation; mucosal ... See more keywords
Liver: Paradigm shift in the immunopathogenesis of NAFLD
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.95
Abstract: ment and fibrotic progression of nonalcoholic fatty liver disease (NAFLD) from nonalcoholic steatohepatitis (NASH) to cirrhosis has been proposed to stem from chronic, low-level type 1 inflammation in adipose tissue. However, new research challenges this… read more here.
Keywords: paradigm shift; shift immunopathogenesis; type inflammation; inflammation ... See more keywords
Type 2 inflammation suppression by T regulatory cells attenuates the eosinophil recruitment in mucosa of chronic sinusitis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20190388
Abstract: Type 2 inflammation and eosinophilic infiltration are prominent pathologic features of chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of the present study was to determine the roles of Tregs in controlling Type 2 inflammation… read more here.
Keywords: chronic sinusitis; inflammation; recruitment mucosa; crswnp ... See more keywords
Can biomarkers help us hit targets in difficult‐to‐treat asthma?
Sign Up to like & getrecommendations! Published in 2017 at "Respirology"
DOI: 10.1111/resp.13014
Abstract: Biomarkers may be a key foundation for the precision medicine of the future. In this article, we review current knowledge regarding biomarkers in difficult‐to‐treat asthma and their ability to guide the use of both conventional… read more here.
Keywords: difficult treat; treat asthma; biomarkers help; type inflammation ... See more keywords
Change in biomarkers of type-2 inflammation following severe exacerbations of asthma
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thoraxjnl-2018-211657
Abstract: We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×109/L, p read more here.
Keywords: following severe; biomarkers type; change; type inflammation ... See more keywords
Increased SERPINB10 Expression in Induced Sputum Was Associated with Airway Type 2 Inflammation in Asthma
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000524613
Abstract: Background: Asthma is a common chronic airway inflammation in the world. The aim of this study was to investigate the expression of SERPINB10 in induced sputum and its correlation with airway type 2 inflammation in… read more here.
Keywords: induced sputum; airway type; type inflammation; inflammation ... See more keywords
IFN‐stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201706-1070oc
Abstract: Rationale: Quantification of type 2 inflammation provided a molecular basis for heterogeneity in asthma. Non‐type 2 pathways that contribute to asthma pathogenesis are not well understood. Objectives: To identify dysregulated pathways beyond type 2 inflammation.… read more here.
Keywords: isg expression; stress; type inflammation; inflammation ... See more keywords
Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know?
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2021-0550ed
Abstract: Allergic asthma is a chronic respiratory disease characterized by profound changes to the structure of the airway wall, resulting in reversible airway obstruction. Although it is currently well understood that these structural and functional changes… read more here.
Keywords: inflammation; cell; type inflammation; wnt ... See more keywords