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   Articles with "type innate" as a keyword



Interleukin‐33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma

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recommendations! Published in 2023 at "Clinical and Translational Allergy"

DOI: 10.1002/clt2.12265

Abstract: Abstract Background Interleukin‐33 (IL‐33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic asthma (EA) and ILC2s remains obscure, and the mechanisms by which IL‐33 affects ILC2s are yet… read more here.

Keywords: interleukin; eosinophilic asthma; innate lymphoid; ilc2s ... See more keywords

Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.29287

Abstract: Type 2 innate lymphoid cells (ILC2s) have multiple functions that can respond to allergic diseases, parasite infection, metabolic homeostasis, tissue repair, and adipose metabolism homeostasis. In these diseases, ILC2s can be activated by various inflammatory… read more here.

Keywords: innate lymphoid; type innate; tumor immunity; tumor ... See more keywords

Interactions between the microbiota and innate and innate‐like lymphocytes

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recommendations! Published in 2018 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3ri0917-378r

Abstract: The microbiota, which consists of commensal bacteria, fungi, and viruses, limits the colonization of pathogens at barrier tissues and promotes immune homeostasis. The latter is accomplished through the induction and regulation of both innate and… read more here.

Keywords: innate; like lymphocytes; innate innate; type innate ... See more keywords

Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.

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recommendations! Published in 2019 at "Immunity"

DOI: 10.1016/j.immuni.2019.11.004

Abstract: Although type 1 innate lymphoid cells (ILC1s) have been originally found as liver-resident ILCs, their pathophysiological role in the liver remains poorly investigated. Here, we demonstrated that carbon tetrachloride (CCl4) injection into mice activated ILC1s,… read more here.

Keywords: type innate; acute liver; innate lymphoid; lymphoid cells ... See more keywords

Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection

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recommendations! Published in 2021 at "Immunity"

DOI: 10.1016/j.immuni.2021.08.002

Abstract: Summary Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping… read more here.

Keywords: fate mapping; mapping single; type innate; infection ... See more keywords

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

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recommendations! Published in 2019 at "iScience"

DOI: 10.1016/j.isci.2019.05.011

Abstract: Summary A short form of cellular FLICE-inhibitory protein encoded by CFLARs promotes necroptosis. Although necroptosis is involved in various pathological conditions, the detailed mechanisms are not fully understood. Here we generated transgenic mice wherein CFLARs… read more here.

Keywords: epithelial cells; intestinal epithelial; cflars mice; type innate ... See more keywords
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Type-2 innate lymphoid cells control the development of atherosclerosis in mice

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms15781

Abstract: Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to… read more here.

Keywords: type; innate lymphoid; type innate; development atherosclerosis ... See more keywords

A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-023-05536-0

Abstract: Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention, ILC2s can also enhance… read more here.

Keywords: biology; tumour expansion; type innate; cell ... See more keywords

IRF3 Promotes Asthma Pathogenesis by Regulating Type 2 Innate Lymphoid Cells

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recommendations! Published in 2024 at "Immunological Investigations"

DOI: 10.1080/08820139.2024.2418935

Abstract: ABSTRACT Background Allergic asthma is characterized by airway hyperresponsiveness triggered by inhaled allergens. Type 2 innate lymphoid cells (ILC2s) have been demonstrated to play a crucial role in promoting airway inflammation through the secretion of… read more here.

Keywords: irf3; lymphoid cells; type innate; innate lymphoid ... See more keywords

BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells

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recommendations! Published in 2018 at "Brain"

DOI: 10.1093/brain/awy173

Abstract: The transcription factor BCL11B is essential for development of the nervous and the immune system, and Bcl11b deficiency results in structural brain defects, reduced learning capacity, and impaired immune cell development in mice. However, the… read more here.

Keywords: bcl11b; type innate; innate lymphoid; lymphoid cells ... See more keywords

The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkaf001

Abstract: Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is required for ILC2s and some ILC3s, its role in ILC1 development remains controversial. To… read more here.

Keywords: ror required; ror; lymphoid cells; type innate ... See more keywords