Interleukin‐33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12265
Abstract: Abstract Background Interleukin‐33 (IL‐33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic asthma (EA) and ILC2s remains obscure, and the mechanisms by which IL‐33 affects ILC2s are yet… read more here.
Keywords: interleukin; eosinophilic asthma; innate lymphoid; ilc2s ... See more keywords
Role of type 2 innate lymphoid cell and its related cytokines in tumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29287
Abstract: Type 2 innate lymphoid cells (ILC2s) have multiple functions that can respond to allergic diseases, parasite infection, metabolic homeostasis, tissue repair, and adipose metabolism homeostasis. In these diseases, ILC2s can be activated by various inflammatory… read more here.
Keywords: innate lymphoid; type innate; tumor immunity; tumor ... See more keywords
Interactions between the microbiota and innate and innate‐like lymphocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ri0917-378r
Abstract: The microbiota, which consists of commensal bacteria, fungi, and viruses, limits the colonization of pathogens at barrier tissues and promotes immune homeostasis. The latter is accomplished through the induction and regulation of both innate and… read more here.
Keywords: innate; like lymphocytes; innate innate; type innate ... See more keywords
Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.11.004
Abstract: Although type 1 innate lymphoid cells (ILC1s) have been originally found as liver-resident ILCs, their pathophysiological role in the liver remains poorly investigated. Here, we demonstrated that carbon tetrachloride (CCl4) injection into mice activated ILC1s,… read more here.
Keywords: type innate; acute liver; innate lymphoid; lymphoid cells ... See more keywords
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.08.002
Abstract: Summary Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping… read more here.
Keywords: fate mapping; mapping single; type innate; infection ... See more keywords
Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.05.011
Abstract: Summary A short form of cellular FLICE-inhibitory protein encoded by CFLARs promotes necroptosis. Although necroptosis is involved in various pathological conditions, the detailed mechanisms are not fully understood. Here we generated transgenic mice wherein CFLARs… read more here.
Keywords: epithelial cells; intestinal epithelial; cflars mice; type innate ... See more keywords
Type-2 innate lymphoid cells control the development of atherosclerosis in mice
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15781
Abstract: Type-2 innate lymphoid cells (ILC2) are a prominent source of type II cytokines and are found constitutively at mucosal surfaces and in visceral adipose tissue. Despite their role in limiting obesity, how ILC2s respond to… read more here.
Keywords: type; innate lymphoid; type innate; development atherosclerosis ... See more keywords
BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells
Sign Up to like & getrecommendations! Published in 2018 at "Brain"
DOI: 10.1093/brain/awy173
Abstract: The transcription factor BCL11B is essential for development of the nervous and the immune system, and Bcl11b deficiency results in structural brain defects, reduced learning capacity, and impaired immune cell development in mice. However, the… read more here.
Keywords: bcl11b; type innate; innate lymphoid; lymphoid cells ... See more keywords
Eosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14284
Abstract: We report a case of eosinophilic fasciitis triggered by strenuous physical activity, which did not relapse during the follow‐up period. We ascertained that interleukin‐33 (IL‐33) was released from the vascular endothelial cells after intense exercise,… read more here.
Keywords: game drumming; eosinophilic fasciitis; type innate; fasciitis ... See more keywords
Reduced type 3 innate lymphoid cells related to worsening kidney function in renal dysfunction
Sign Up to like & getrecommendations! Published in 2023 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221147561
Abstract: Intestinal mucosa barrier injury and immunity imbalance contribute to chronic kidney disease (CKD) progression. Type 3 innate lymphoid cells (ILC3s) are essential for normal intestinal homeostasis. Nevertheless, the relationship between ILC3s and CKD remains largely… read more here.
Keywords: kidney function; function; type innate; renal dysfunction ... See more keywords
1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1886-p
Abstract: Type 2 innate lymphoid cells (ILC2s) were recently identified as essential components of innate immunity. Besides, beneficial roles of ILC2s in metabolic diseases are attracting attentions. Although the liver contains various immune cells including T… read more here.
Keywords: mice; gluconeogenesis; innate lymphoid; ilc2s ... See more keywords