Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202510816
Abstract: Monocyte-derived cells, including osteoclasts, dendritic cells, and macrophages, are key components of the immunosuppressive tumor microenvironment in multiple myeloma (MM). However, the mechanisms linking monocyte dysfunction to immune evasion remain incompletely understood. In this study,… read more here.
Keywords: multiple myeloma; type; activation; type interferon ... See more keywords
Type‐I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS‐CoV‐2 and other viral infections
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048978
Abstract: Low concentrations of type‐I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID‐19). However, following the type‐I interferon response (IR) in early stage disease is a major… read more here.
Keywords: type interferon; using filmarray; interferon; minutes using ... See more keywords
Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249913
Abstract: SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I… read more here.
Keywords: ifn; innate immune; responses sars; type interferon ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
Age‐related transcript changes in type I interferon signaling in children and adolescents with long COVID
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202350682
Abstract: SARS‐CoV‐2 typically causes mild symptoms in children, but evidence suggests that persistent immunopathological changes may lead to long COVID (LC). To explore the interplay between LC and innate immunity, we assessed the type I interferon… read more here.
Keywords: age; ifn ifn; children adolescents; type interferon ... See more keywords
Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451382
Abstract: The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and trigger type I interferon (IFN‐I) responses, which are crucial for antiviral defense. NA pattern recognition receptors detect viral RNA or… read more here.
Keywords: nucleic acid; type interferon; susceptibility; viral infections ... See more keywords
Assays to Demonstrate the Roles of Arenaviral Nucleoproteins (NPs) in Viral RNA Synthesis and in Suppressing Type I Interferon.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6981-4_13
Abstract: Arenaviruses, such as Lassa virus (LASV) and Pichindé virus (PICV), are enveloped viruses with a bi-segmented ambisense RNA genome. The large (L) genomic segment encodes the Z matrix protein and the L RNA-dependent RNA polymerase,… read more here.
Keywords: demonstrate roles; assays demonstrate; rna; type interferon ... See more keywords
Type I interferon pathway in pediatric systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2024 at "World Journal of Pediatrics"
DOI: 10.1007/s12519-024-00811-4
Abstract: The role of type I interferon (IFN-I) signaling in systemic lupus erythematosus (SLE) has been well established. However, unanswered questions remain regarding the applicability of these findings to pediatric-onset SLE. The aim of this review… read more here.
Keywords: sle; systemic lupus; interferon; type interferon ... See more keywords
Efficacy and Safety of Janus Kinase Inhibitors in Type I Interferon-Mediated Monogenic Autoinflammatory Disorders: A Scoping Review
Sign Up to like & getrecommendations! Published in 2021 at "Dermatology and Therapy"
DOI: 10.1007/s13555-021-00517-9
Abstract: Type I interferon (IFN)-mediated monogenic autoinflammatory disorders (interferonopathies) are childhood-onset rare multisystemic diseases with limited treatment options. The Janus kinase (JAK) inhibitors are promising potential therapeutic candidates for immune-mediated chronic inflammatory skin diseases. To review… read more here.
Keywords: type interferon; mediated monogenic; monogenic autoinflammatory; safety ... See more keywords
Does type-I interferon drive systemic autoimmunity?
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2017.07.001
Abstract: Type-I interferon (IFN)-mediated immune response involves both innate and adaptive immune system and has a pivotal role in antiviral defence. A complex interplay of intracellular signaling pathways and tight regulatory systems drive the IFN activation.… read more here.
Keywords: drive systemic; type interferon; autoimmunity;
Antagonism of type I interferon by flaviviruses.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.146
Abstract: The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a large family of arthropod-borne positive-stranded RNA viruses, many of which represent… read more here.
Keywords: type; antagonism type; interferon flaviviruses; type interferon ... See more keywords