Type‐I Interferon assessment in 45 minutes using the FilmArray® PCR platform in SARS‐CoV‐2 and other viral infections
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048978
Abstract: Low concentrations of type‐I interferon (IFN) in blood seem to be associated with more severe forms of Coronavirus disease 2019 (COVID‐19). However, following the type‐I interferon response (IR) in early stage disease is a major… read more here.
Keywords: type interferon; using filmarray; interferon; minutes using ... See more keywords
Type I interferon signaling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249913
Abstract: SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I… read more here.
Keywords: ifn; innate immune; responses sars; type interferon ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
Assays to Demonstrate the Roles of Arenaviral Nucleoproteins (NPs) in Viral RNA Synthesis and in Suppressing Type I Interferon.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6981-4_13
Abstract: Arenaviruses, such as Lassa virus (LASV) and Pichindé virus (PICV), are enveloped viruses with a bi-segmented ambisense RNA genome. The large (L) genomic segment encodes the Z matrix protein and the L RNA-dependent RNA polymerase,… read more here.
Keywords: demonstrate roles; assays demonstrate; rna; type interferon ... See more keywords
Efficacy and Safety of Janus Kinase Inhibitors in Type I Interferon-Mediated Monogenic Autoinflammatory Disorders: A Scoping Review
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DOI: 10.1007/s13555-021-00517-9
Abstract: Type I interferon (IFN)-mediated monogenic autoinflammatory disorders (interferonopathies) are childhood-onset rare multisystemic diseases with limited treatment options. The Janus kinase (JAK) inhibitors are promising potential therapeutic candidates for immune-mediated chronic inflammatory skin diseases. To review… read more here.
Keywords: type interferon; mediated monogenic; monogenic autoinflammatory; safety ... See more keywords
Does type-I interferon drive systemic autoimmunity?
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DOI: 10.1016/j.autrev.2017.07.001
Abstract: Type-I interferon (IFN)-mediated immune response involves both innate and adaptive immune system and has a pivotal role in antiviral defence. A complex interplay of intracellular signaling pathways and tight regulatory systems drive the IFN activation.… read more here.
Keywords: drive systemic; type interferon; autoimmunity;
Antagonism of type I interferon by flaviviruses.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.146
Abstract: The prompt and tightly controlled induction of type I interferon is a central event of the immune defense against viral infection. Flaviviruses comprise a large family of arthropod-borne positive-stranded RNA viruses, many of which represent… read more here.
Keywords: type; antagonism type; interferon flaviviruses; type interferon ... See more keywords
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
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DOI: 10.1016/j.ccell.2021.06.018
Abstract: PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition… read more here.
Keywords: type interferon; parp7; cancer; cells inhibition ... See more keywords
Type I interferon-mediated autoinflammation and autoimmunity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.09.003
Abstract: The monogenic type I interferonopathies comprise a heterogenous group of disorders of the innate immune system associated with constitutive activation of antiviral type I interferon (IFN). Despite a remarkable phenotypic diversity, type I interferonopathies are… read more here.
Keywords: autoinflammation; type interferon; interferon mediated; autoimmunity ... See more keywords
Type I interferon in the pathogenesis of systemic lupus erythematosus.
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DOI: 10.1016/j.coi.2020.10.014
Abstract: Type I interferon (IFN) is a primary pathogenic factor in systemic lupus erythematosus (SLE). Gain-of-function genetic variants in the type I IFN pathway have been associated with risk of disease. Common polygenic as well as… read more here.
Keywords: type interferon; systemic lupus; lupus erythematosus; type ifn ... See more keywords
Type I Interferon in Chronic Virus Infection and Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in immunology"
DOI: 10.1016/j.it.2017.05.005
Abstract: Type I interferons (IFN-Is) are emerging as key drivers of inflammation and immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; however, prolonged IFN-I signaling can lead to immune dysfunction. IFN-Is are also… read more here.
Keywords: cancer; chronic virus; infection; type interferon ... See more keywords