Type I interferons provide additive signals for murine regulatory B cell induction by Schistosoma mansoni eggs
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847858
Abstract: The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)‐10‐producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized.… read more here.
Keywords: mansoni; type interferons; ifn; schistosoma mansoni ... See more keywords
Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-021-01060-0
Abstract: Convalescent plasma has been a mainstay therapeutic in passive immunization for decades. In the setting of the novel coronavirus (SARS-CoV-2), it has become widely used for prophylaxis and early intervention in COVID-19 [1, 2]. Recently,… read more here.
Keywords: type interferons; plasma; donor; covid ... See more keywords
Type I interferons and SARS-CoV-2: from cells to organisms
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Immunology"
DOI: 10.1016/j.coi.2022.01.003
Abstract: Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro produce low levels of type I IFNs, and… read more here.
Keywords: interferons sars; sars cov; type ifns; type interferons ... See more keywords
The role of type I interferons in CD4+ T cell differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.01.013
Abstract: Type I interferons (IFNs) released upon viral infections play different and opposing roles in disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing and target cells for these molecules. The effect… read more here.
Keywords: type interferons; role type; differentiation; role ... See more keywords
Do Type I Interferons Link Systemic Autoimmunities and Metabolic Syndrome in a Pathogenetic Continuum?
Sign Up to like & getrecommendations! Published in 2018 at "Trends in immunology"
DOI: 10.1016/j.it.2017.07.001
Abstract: The central pathogenetic role of type I interferons (IFNs) in several systemic autoimmune diseases is well established. Recent studies have also discovered a similar crucial role of type I IFNs in different components of metabolic… read more here.
Keywords: autoimmunities metabolic; pathogenetic continuum; type interferons; systemic autoimmunities ... See more keywords
Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16869-2
Abstract: Emergency monocytopoiesis is an inflammation-driven hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Yet, the regulatory mechanisms by which early bone marrow myeloid progenitors commit to monocyte-derived… read more here.
Keywords: type interferons; emergency monocytopoiesis; monocytopoiesis; dendritic cells ... See more keywords
Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1314424
Abstract: ABSTRACT If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the… read more here.
Keywords: type interferons; type ifns; cancer; interferons infection ... See more keywords
Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000495897
Abstract: The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic,… read more here.
Keywords: type interferons; biological activities; ifn; ifn ifn ... See more keywords
DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007125
Abstract: Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed. Because arenavirus… read more here.
Keywords: type interferons; interferons favors; ddx3 suppresses; suppresses type ... See more keywords
Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19531
Abstract: During the last decades, the pleiotropic antitumor functions exerted by type I interferons (IFNs) have become universally acknowledged, especially their role in mediating interactions between the tumor and the immune system. Indeed, type I IFNs… read more here.
Keywords: cancer; type interferons; cancer therapy; antitumor effects ... See more keywords
Type 1 Interferons Potentiate Human CD8+ T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes"
DOI: 10.2337/db17-0106
Abstract: Events defining the progression to human type 1 diabetes (T1D) have remained elusive owing to the complex interaction between genetics, the immune system, and the environment. Type 1 interferons (T1-IFN) are known to be a… read more here.
Keywords: cd8 cell; type interferons; cell; cytotoxicity ... See more keywords