Exosomes derived from induced pluripotent stem cells suppresses M2-type macrophages during pulmonary fibrosis via miR-302a-3p/TET1 axis.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108075
Abstract: Idiopathic pulmonary fibrosis (PF) is a type of chronic lung disease. Here, we investigated the effect of induced pluripotent stem cell (iPSC)-derived exosomes (iPSC-exosomes) on M2-type macrophages which play a critical role in pulmonary fibrosis.… read more here.
Keywords: type macrophages; mir 302a; ipsc exosomes; pulmonary fibrosis ... See more keywords
A core-shell structure QRu-PLGA-RES-DS NP nanocomposite with photothermal response-induced M2 macrophage polarization for rheumatoid arthritis therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr05922a
Abstract: Rheumatoid arthritis (RA) is a degenerative joint disease caused by autoimmunity; for the effective treatment of RA while avoiding the side effects of conventional drugs, we have proposed a new therapeutic strategy to eliminate the… read more here.
Keywords: type macrophages; response; qru plga; shell ... See more keywords
M2-Type Macrophages and Cancer-Associated Fibroblasts Combine to Promote Colorectal Cancer Liver Metastases
Sign Up to like & getrecommendations! Published in 2024 at "OncoTargets and Therapy"
DOI: 10.2147/ott.s447502
Abstract: Purpose This research explored the association between CD163-labeled M2-type macrophages and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) of 38 colorectal cancer (CRC) liver metastases. In addition, we investigated the correlation differences between M2-type… read more here.
Keywords: colorectal cancer; macrophages cafs; cancer; liver metastases ... See more keywords
Dextran Sulfate Inhibits Angiogenesis and Invasion of Gastric Cancer by Interfering with M2-type Macrophages Polarization.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220705095403
Abstract: Purpose To explore the effect of dextran sulfate (DS) on the angiogenesis, invasion, and migration of gastric cancer cells through interfering with the polarization of M2-type macrophages. Methods The infiltration of M2-type macrophages and microvascular… read more here.
Keywords: type macrophages; gastric cancer; polarization; angiogenesis invasion ... See more keywords
Blister Fluid Induces MMP-9-Associated M2-Type Macrophages in Bullous Pemphigoid
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01858
Abstract: Bullous pemphigoid (BP) is a cutaneous autoimmune disease, characterized by an inflammatory cascade leading to blister formation. Although macrophages were shown to participate in BP pathophysiology, their role in the blister formation process still needs… read more here.
Keywords: bullous pemphigoid; type macrophages; blister fluid; blister ... See more keywords
Dectin-1 participates in the immune-inflammatory response to mouse Aspergillus fumigatus keratitis by modulating macrophage polarization
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1431633
Abstract: Aim The aim of this study was to investigate whether Dectin-1 influences the immune-inflammatory response in A. fumigatus keratitis by modulating macrophage polarization. Methods 1. The models of 1-day, 3-day, and 5-day of fungal keratitis… read more here.
Keywords: fumigatus keratitis; type macrophages; group; pretreatment group ... See more keywords
Substance P promotes epidural fibrosis via induction of type 2 macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.369120
Abstract: [INLINE:1] In response to spinal surgery, neurons secrete a large amount of substance P into the epidural area. Substance P is involved in macrophage differentiation and fibrotic disease. However, the specific roles and mechanisms of… read more here.
Keywords: differentiation; substance; epidural fibrosis; type macrophages ... See more keywords