PGC-1β modulates statin-associated myotoxicity in mice
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2369-7
Abstract: Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. Statins are generally well tolerated, but can be associated with potentially life-threatening myopathy of unknown mechanism. We have shown previously that statins impair PGC-1β expression in… read more here.
Keywords: skeletal muscle; type mice; muscle; pgc ... See more keywords
Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1840-x
Abstract: Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated… read more here.
Keywords: type mice; ultraviolet radiation; mice; wild type ... See more keywords
Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.13873
Abstract: The Lyme disease spirochete evades the host immune system by combinatorial variation of VlsE, a surface antigen. Antigenic variation occurs via segmental gene conversion from contiguous silent cassettes into the vlsE locus. Because of the… read more here.
Keywords: pacbio sequencing; variation; antigenic variation; pipeline ... See more keywords
Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180981
Abstract: Plasminogen (Plg) is a precursor of plasmin that degrades fibrin. A race-specific A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity.… read more here.
Keywords: type mice; plg; mice; wild type ... See more keywords
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147609
Abstract: Despite the growing list of identified SARS-CoV-2 receptors, the human angiotensin-converting enzyme 2 (ACE2) is still viewed as the main cell entry receptor mediating SARS-CoV-2 internalization. It has been reported that wild-type mice, like other… read more here.
Keywords: internalization; type mice; inactivated sars; sars cov ... See more keywords
Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9080653
Abstract: Prion disease is a group of transmissible neurodegenerative disorders affecting humans and animals. The prion hypothesis postulates that PrPSc, the pathogenic conformer of host-encoded prion protein (PrP), is the unconventional proteinaceous infectious agent called prion.… read more here.
Keywords: disease wild; type mice; prion; prion disease ... See more keywords