PGC-1β modulates statin-associated myotoxicity in mice
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2369-7
Abstract: Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. Statins are generally well tolerated, but can be associated with potentially life-threatening myopathy of unknown mechanism. We have shown previously that statins impair PGC-1β expression in… read more here.
Keywords: skeletal muscle; type mice; muscle; pgc ... See more keywords
Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1840-x
Abstract: Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated… read more here.
Keywords: type mice; ultraviolet radiation; mice; wild type ... See more keywords
A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-92400-2
Abstract: FKBP5 is a 51-Da FK506-binding protein and member of the immunophilin family involved in controlling the signaling of glucocorticoid receptor from the cytosol to nucleus. Fkbp5 has previously been shown to be expressed in murine… read more here.
Keywords: fkbp5; mice; mitogen activated; type mice ... See more keywords
Interleukin-22 inhibits right ventricular remodelling by a unique mechanism in a pulmonary artery constriction model
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.3758
Abstract: Fibrosis and remodeling of right ventricle (RV) are associated with prognosis in patients with RV failure. Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, play roles in tissue protection and wound repair. We… read more here.
Keywords: mice; type mice; wild type; mechanism ... See more keywords
Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.13873
Abstract: The Lyme disease spirochete evades the host immune system by combinatorial variation of VlsE, a surface antigen. Antigenic variation occurs via segmental gene conversion from contiguous silent cassettes into the vlsE locus. Because of the… read more here.
Keywords: pacbio sequencing; variation; antigenic variation; pipeline ... See more keywords
Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180981
Abstract: Plasminogen (Plg) is a precursor of plasmin that degrades fibrin. A race-specific A620T mutation in Plg, also known as Plg-Tochigi, originally identified in a patient with recurrent venous thromboembolism, causes dysplasminogenemia with reduced plasmin activity.… read more here.
Keywords: type mice; plg; mice; wild type ... See more keywords
Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147609
Abstract: Despite the growing list of identified SARS-CoV-2 receptors, the human angiotensin-converting enzyme 2 (ACE2) is still viewed as the main cell entry receptor mediating SARS-CoV-2 internalization. It has been reported that wild-type mice, like other… read more here.
Keywords: internalization; type mice; inactivated sars; sars cov ... See more keywords
Oral Ingestion of Synthetically Generated Recombinant Prion Is Sufficient to Cause Prion Disease in Wild-Type Mice
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens"
DOI: 10.3390/pathogens9080653
Abstract: Prion disease is a group of transmissible neurodegenerative disorders affecting humans and animals. The prion hypothesis postulates that PrPSc, the pathogenic conformer of host-encoded prion protein (PrP), is the unconventional proteinaceous infectious agent called prion.… read more here.
Keywords: disease wild; type mice; prion; prion disease ... See more keywords