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   Articles with "type nadh" as a keyword



Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases

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recommendations! Published in 2022 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.2c01493

Abstract: It is critical that novel classes of antituberculosis drugs are developed to combat the increasing burden of infections by multidrug-resistant strains. To identify such a novel class of antibiotics, a chemical library of unique 3-D… read more here.

Keywords: kill mycobacteria; tricyclic spirolactams; type nadh; spirolactams kill ... See more keywords

Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)

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recommendations! Published in 2022 at "ACS Infectious Diseases"

DOI: 10.1021/acsinfecdis.1c00413

Abstract: Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuberculosis… read more here.

Keywords: quinolinyl pyrimidines; type nadh; nadh dehydrogenase; dehydrogenase ndh ... See more keywords

2-Aryl-Benzoimidazoles as Type II NADH Dehydrogenase Inhibitors of Mycobacterium tuberculosis.

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recommendations! Published in 2024 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.4c00710

Abstract: The nonproton pumping type II NADH dehydrogenase in Mycobacterium tuberculosis is essential for meeting the energy needs in terms of ATP under normal aerobic and stressful hypoxic environmental states. Type II NADH dehydrogenase conduits electrons… read more here.

Keywords: mycobacterium tuberculosis; type nadh; nadh dehydrogenase;

Myricetin Acts as an Inhibitor of Type II NADH Dehydrogenase from Staphylococcus aureus

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recommendations! Published in 2024 at "Molecules"

DOI: 10.3390/molecules29102354

Abstract: Background: Staphylococcus aureus is a common pathogenic microorganism in humans and animals. Type II NADH oxidoreductase (NDH-2) is the only NADH:quinone oxidoreductase present in this organism and represents a promising target for the development of… read more here.

Keywords: inhibitor ndh; inhibitor; myricetin; staphylococcus aureus ... See more keywords