Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
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DOI: 10.1038/s41467-019-12941-9
Abstract: Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting molecule CD1d. While we have an understanding of the antigen reactivity and function of type I NKT cells, our… read more here.
Keywords: nkt cells; antigen; type; cell ... See more keywords
CD1d-Restricted Type II NKT Cells Reactive With Endogenous Hydrophobic Peptides
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DOI: 10.3389/fimmu.2018.00548
Abstract: NKT cells belong to a distinct subset of T cells that recognize hydrophobic antigens presented by major histocompatibility complex class I-like molecules, such as CD1d. Because NKT cells stimulated by antigens can activate or suppress… read more here.
Keywords: type nkt; nkt cells; restricted type; cd1d restricted ... See more keywords
Type II NKT Cells: An Elusive Population With Immunoregulatory Properties
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01969
Abstract: Natural killer T (NKT) cells are unique unconventional T cells that are reactive to lipid antigens presented on the non-polymorphic major histocompatibility class (MHC) I-like molecule CD1d. They have characteristics of both innate and adaptive… read more here.
Keywords: population; cells elusive; type nkt; nkt cells ... See more keywords
Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01065
Abstract: Background: Natural Killer T (NKT) cells are CD1d-restricted innate-like T cells that can rapidly release stored cytokines upon recognition of lipid antigens. In mice, type I NKT cells seem to promote liver inflammation, whereas type… read more here.
Keywords: reactive type; sulfatide reactive; type nkt; nkt cells ... See more keywords
Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection
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DOI: 10.3389/fimmu.2020.610010
Abstract: Methicillin-resistant Staphylococcus aureus (SA) bacteremia is responsible for over 10,000 deaths in the hospital setting each year. Both conventional CD4+ T cells and γδ T cells play protective roles in SA infection through secretion of… read more here.
Keywords: staphylococcus aureus; infection; resistant staphylococcus; nkt cells ... See more keywords
Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19030752
Abstract: Natural Killer T cells (NKT cells) are emerging as critical regulators of pro- and anti-tumor immunity, both at baseline and in therapeutic settings. While type I NKT cells can promote anti-tumor immunity, their activity in… read more here.
Keywords: btla; type nkt; nkt cells; tumor ... See more keywords