Guardian of genome on the tract: wild type p53-mdm2 complex inhibition in healing the breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Gene"
DOI: 10.1016/j.gene.2021.145616
Abstract: Breast cancer acts as an assassin among women. According to WHO (world health organisation), about 6, 27,000 deaths have occurred in 2018 due to breast cancer. Since, the evolution of cancer involves many complicated pathway,… read more here.
Keywords: breast cancer; type p53; cancer; p53 ... See more keywords
Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05805-1
Abstract: There are considerable challenges in directly targeting the mutant p53 protein, given the large heterogeneity of p53 mutations in the clinic. An alternative approach is to exploit the altered fitness of cells imposed by loss-of-wild-type… read more here.
Keywords: mitochondrial uncoupling; type p53; mutant p53; p53 deficient ... See more keywords
Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.
Sign Up to like & getrecommendations! Published in 2020 at "NPJ breast cancer"
DOI: 10.1038/s41523-019-0143-5
Abstract: Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic… read more here.
Keywords: type p53; expression; melk expression; p53 ... See more keywords
AGR2-dependent nuclear import of RNA polymerase II constitutes a specific target of pancreatic ductal adenocarcinoma in the context of wild-type p53.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.07.030
Abstract: BACKGROUND AND AIM Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). Agr2 (anterior gradient 2), a known inhibitor of p53, is detected at early… read more here.
Keywords: rnapii; wild type; type p53; nuclear import ... See more keywords
Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aao4170
Abstract: Contrary to previous reports, wild-type p53 can interact with p73 to promote cell stress–induced apoptosis. Another look at p53-p73 interactions The transcription factor p53 critically regulates cell survival or death in response to cellular stress.… read more here.
Keywords: p73; type p53; p53; cell ... See more keywords
The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0440
Abstract: Radiotherapy amplifies p53 expression in cancer cells with wild-type (wt) p53. Blocking the negative regulators MDM2 and MDMX stabilizes p53 and may therefore potentiate radiotherapy outcomes. In this study, we investigate the efficacy of the… read more here.
Keywords: pm2; radiotherapy; type p53; p53 ... See more keywords
CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15977
Abstract: Abstract Background/Aim: The development of pharmacological inhibitors targeting negative regulators of p53, such as murine double minute (MDM) 2 and, more recently, MDM4, has been actively pursued as a potential strategy to treat cancers with… read more here.
Keywords: type p53; expression; glioma; p53 ... See more keywords
Tumor Suppressor Role of Wild-Type P53-Dependent Secretome and Its Proteomic Identification in PDAC
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020305
Abstract: The study of the cancer secretome is gaining even more importance in cancers such as pancreatic ductal adenocarcinoma (PDAC), whose lack of recognizable symptoms and early detection assays make this type of cancer highly lethal.… read more here.
Keywords: type p53; p53; pdac; cancer ... See more keywords
Role of wild-type p53-induced phosphatase 1 in cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.6685
Abstract: Wild-type p53-induced phosphatase (Wip1) is a member of the protein phosphatase type 2C family and is an established oncogene due to its dephosphorylation of several tumor suppressors and negative control of the DNA damage response… read more here.
Keywords: p53 induced; type p53; role; cancer ... See more keywords