A phage protein-derived antipathogenic peptide that targets type IV pilus assembly
Sign Up to like & getrecommendations! Published in 2021 at "Virulence"
DOI: 10.1080/21505594.2021.1926411
Abstract: ABSTRACT Phage-inspired antibacterial discovery is a new approach that recruits phages in search for antibacterials with new molecular targets, in that phages are the biological entities well adapted to hijack host bacterial physiology in favor… read more here.
Keywords: peptide; antipathogenic peptide; phage; type pilus ... See more keywords
Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.10.24.513447
Abstract: Type IV pilus (TFP) is a multifunctional bacterial structure involved in twitching motility, adhesion, biofilm formation, as well as natural competence. Here, by mutagenesis and functional analysis, we dissected the roles of all genes required… read more here.
Keywords: reemergent plant; functional analysis; type pilus; plant ... See more keywords
Discovery of a New Neisseria gonorrhoeae Type IV Pilus Assembly Factor, TfpC
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.02528-20
Abstract: Most bacterial species express one or more extracellular organelles called pili/fimbriae that are required for many properties of each bacterial cell. The Neisseria gonorrhoeae type IV pilus is a major virulence and colonization factor for… read more here.
Keywords: tfpc; type pilus; neisseria gonorrhoeae; bacterial cell ... See more keywords
Type IV Pilus Shapes a ‘Bubble-Burst’ Pattern Opposing Spatial Intermixing of Two Interacting Bacterial Populations
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01944-21
Abstract: When growing on surfaces, multispecies microbial communities form biofilms that exhibit intriguing spatial patterns. These patterns can significantly affect the overall properties of the community, enabling otherwise impermissible metabolic functions to occur as well as… read more here.
Keywords: spatial intermixing; spatial patterns; microbial communities; pattern ... See more keywords
Multiple conformations facilitate PilT function in the type IV pilus.
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.2210/pdb6olj/pdb
Abstract: Type IV pilus-like systems are protein complexes that polymerize pilin fibres. They are critical for virulence in many bacterial pathogens. Pilin polymerization and depolymerization are powered by motor ATPases of the PilT/VirB11-like family. This family… read more here.
Keywords: pilt function; type pilus; family; function ... See more keywords
The Flp type IV pilus operon of Mycobacterium tuberculosis is expressed upon interaction with macrophages and alveolar epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.916247
Abstract: The genome of Mycobacterium tuberculosis (Mtb) harbors the genetic machinery for assembly of the Fimbrial low-molecular-weight protein (Flp) type IV pilus. Presumably, the Flp pilus is essential for pathogenesis. However, it remains unclear whether the… read more here.
Keywords: mycobacterium tuberculosis; pili; flp; flp type ... See more keywords
Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.31662
Abstract: Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits,… read more here.
Keywords: pilus; pilus rod; type pilus; functional role ... See more keywords