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   Articles with "type pilus" as a keyword



Structures of the Escherichia coli type 1 pilus during pilus rod assembly and after assembly termination

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60325-z

Abstract: Uropathogenic Escherichia coli strains use filamentous type 1 pili to adhere to and invade uroepithelial cells. The pilus consists of a flexible tip fibrillum, formed by the adhesin FimH and the subunits FimG and FimF.… read more here.

Keywords: assembly termination; type pilus; pilus rod; pilus ... See more keywords

A phage protein-derived antipathogenic peptide that targets type IV pilus assembly

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recommendations! Published in 2021 at "Virulence"

DOI: 10.1080/21505594.2021.1926411

Abstract: ABSTRACT Phage-inspired antibacterial discovery is a new approach that recruits phages in search for antibacterials with new molecular targets, in that phages are the biological entities well adapted to hijack host bacterial physiology in favor… read more here.

Keywords: peptide; antipathogenic peptide; phage; type pilus ... See more keywords

Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes

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recommendations! Published in 2022 at "PLOS Pathogens"

DOI: 10.1101/2022.10.24.513447

Abstract: Type IV pilus (TFP) is a multifunctional bacterial structure involved in twitching motility, adhesion, biofilm formation, as well as natural competence. Here, by mutagenesis and functional analysis, we dissected the roles of all genes required… read more here.

Keywords: reemergent plant; functional analysis; type pilus; plant ... See more keywords

Discovery of a New Neisseria gonorrhoeae Type IV Pilus Assembly Factor, TfpC

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recommendations! Published in 2020 at "mBio"

DOI: 10.1128/mbio.02528-20

Abstract: Most bacterial species express one or more extracellular organelles called pili/fimbriae that are required for many properties of each bacterial cell. The Neisseria gonorrhoeae type IV pilus is a major virulence and colonization factor for… read more here.

Keywords: tfpc; type pilus; neisseria gonorrhoeae; bacterial cell ... See more keywords

Type IV Pilus Shapes a ‘Bubble-Burst’ Pattern Opposing Spatial Intermixing of Two Interacting Bacterial Populations

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01944-21

Abstract: When growing on surfaces, multispecies microbial communities form biofilms that exhibit intriguing spatial patterns. These patterns can significantly affect the overall properties of the community, enabling otherwise impermissible metabolic functions to occur as well as… read more here.

Keywords: spatial intermixing; spatial patterns; microbial communities; pattern ... See more keywords

Flavin affinity for the reductase HpaC differentially sensitizes Neisseria gonorrhoeae during Type IV pilus-dependent killing

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recommendations! Published in 2025 at "PLOS Pathogens"

DOI: 10.1371/journal.ppat.1013607

Abstract: The Neisseria gonorrhoeae Type IV pilus is a dynamic fiber involved in host cell attachment, DNA transformation, twitching motility, and evading the innate immune system. We previously reported that pilus expression affects iron homeostasis and… read more here.

Keywords: gonorrhoeae type; type pilus; hpac; neisseria gonorrhoeae ... See more keywords

Multiple conformations facilitate PilT function in the type IV pilus.

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.2210/pdb6olj/pdb

Abstract: Type IV pilus-like systems are protein complexes that polymerize pilin fibres. They are critical for virulence in many bacterial pathogens. Pilin polymerization and depolymerization are powered by motor ATPases of the PilT/VirB11-like family. This family… read more here.

Keywords: pilt function; type pilus; family; function ... See more keywords

The Flp type IV pilus operon of Mycobacterium tuberculosis is expressed upon interaction with macrophages and alveolar epithelial cells

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recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.916247

Abstract: The genome of Mycobacterium tuberculosis (Mtb) harbors the genetic machinery for assembly of the Fimbrial low-molecular-weight protein (Flp) type IV pilus. Presumably, the Flp pilus is essential for pathogenesis. However, it remains unclear whether the… read more here.

Keywords: mycobacterium tuberculosis; pili; flp; flp type ... See more keywords

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

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recommendations! Published in 2018 at "eLife"

DOI: 10.7554/elife.31662

Abstract: Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits,… read more here.

Keywords: pilus; pilus rod; type pilus; functional role ... See more keywords