Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory Study
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DOI: 10.1097/ccm.0000000000004042
Abstract: Supplemental Digital Content is available in the text. read more here.
Keywords: cycle biomarkers; urokinase type; biomarkers soluble; type plasminogen ... See more keywords
Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000730
Abstract: Objectives Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) are increased in various inflammatory and infectious diseases. We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute… read more here.
Keywords: pancreatitis; type plasminogen; urokinase type; supar ... See more keywords
Prognostic value of soluble urokinase‐type plasminogen activator receptor in coronary artery disease: A meta‐analysis
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DOI: 10.1111/eci.13867
Abstract: A potential inflammatory biomarker, soluble urokinase‐type plasminogen activator receptor (suPAR) has been utilized to assist the prognostic assessment of coronary artery disease (CAD) patients; however, outcomes have been inconsistent. The prognostic relevance of suPAR as… read more here.
Keywords: soluble urokinase; activator receptor; plasminogen activator; type plasminogen ... See more keywords
Compaction of fibrin clots reveals the antifibrinolytic effect of factor XIII: reply
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DOI: 10.1111/jth.13544
Abstract: Danø K, Carmeliet P, Collen D, Degen JL. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc Natl Acad Sci USA 1996; 93: 5899–904. 7… read more here.
Keywords: type plasminogen; compaction fibrin; reveals antifibrinolytic; fibrin clots ... See more keywords
What is the Role of Soluble Urokinase-Type Plasminogen Activator in Renal Disease?
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DOI: 10.1159/000490118
Abstract: Context: Soluble urokinase-type plasminogen activator (suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945–953] it has been found that there… read more here.
Keywords: type plasminogen; renal disease; urokinase type; disease ... See more keywords
Microfluidic Modeling of Thrombolysis: Effect of Antiplatelet and Anticoagulant Agents on tPA (Tissue-Type Plasminogen Activator)-Induced Fibrinolysis
Sign Up to like & getrecommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.118.311178
Abstract: Objective— Despite the high clinical relevance of thrombolysis, models for its study in human flowing blood are lacking. Our objective was to develop a microfluidic model for comparative evaluation of thrombolytic therapeutic strategies. Approach and… read more here.
Keywords: type plasminogen; thrombolysis; fibrinolysis; tissue type ... See more keywords
Agreement Among Stroke Faculty and Fellows in Treating Ischemic Stroke Patients With Tissue-Type Plasminogen Activator and Thrombectomy
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DOI: 10.1161/strokeaha.116.015214
Abstract: Background and Purpose— The aim of this study is to determine agreement among vascular neurology fellows and faculty in treating patients with acute ischemic stroke with intravenous tissue-type plasminogen activator and intra-arterial thrombectomy (IAT). Methods—… read more here.
Keywords: neurology; type plasminogen; agreement; tissue type ... See more keywords
Angioedema After Use of Recombinant Tissue-Type Plasminogen Activators in Stroke
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DOI: 10.1161/strokeaha.124.047060
Abstract: Angioedema without concomitant urticaria is a well-known complication of treatment with the recombinant tissue-type plasminogen activator (r-tPA) alteplase and its genetically modified variant tenecteplase. It is potentially lethal when causing airway obstruction and can require… read more here.
Keywords: tissue type; recombinant tissue; type plasminogen; angioedema ... See more keywords
Tissue-type plasminogen activator regulates macrophage activation and innate immunity.
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DOI: 10.1182/blood-2017-04-780205
Abstract: Tissue-type plasminogen activator (tPA) is the major intravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling. In cultured macrophages, tPA inhibits the response to lipopolysaccharide (LPS) by a pathway that apparently… read more here.
Keywords: type plasminogen; tissue type; tpa; activator ... See more keywords
Tissue-type plasminogen activator expression by endothelial cells and oligodendrocytes is required for proper CNS myelination
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DOI: 10.1186/s40478-025-02110-z
Abstract: Oligodendrocytes form myelin sheaths, a process regulated by intrinsic and extrinsic signals. Endothelial derived-tissue-type plasminogen activator (tPA) has been previously recognized for its role in aiding oligodendrocyte migration during (re)myelination. Moreover, it is well established… read more here.
Keywords: tissue type; myelination; plasminogen activator; type plasminogen ... See more keywords
The cAMP-ERK1/2 signaling pathway regulates urokinase-type plasminogen activator-induced bovine granulosa cell proliferation.
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DOI: 10.1530/rep-20-0165
Abstract: Although urokinase-type plasminogen activator (PLAU) and urokinase-type plasminogen activator receptor (PLAUR) have been reported to play key roles in ovarian function, their precise contribution to mammalian follicular development remains unclear. In this study, we firstly… read more here.
Keywords: type plasminogen; urokinase type; plau plaur; proliferation ... See more keywords