Technical Advances to Accelerate Modular Type I Polyketide Synthase Engineering towards a Retro-biosynthetic Platform
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0083-9
Abstract: Modular type I polyketide synthases (PKSs) are multifunctional proteins that are comprised of individual domains organized into modules. These modules act together to assemble complex polyketides from acyl-CoA substrates in a linear fashion. This assembly-line… read more here.
Keywords: type polyketide; engineering; biosynthetic platform; retro biosynthetic ... See more keywords
Rh-Catalyzed [2 + 2 + 2] Cycloadditions with Benzoquinones: De Novo Access to Naphthoquinones for Lignan and Type II Polyketide Synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b04266
Abstract: The first examples of Rh-catalyzed [2 + 2 + 2] cycloadditions between diynes and benzoquinones are described. The method enables de novo and step-economical access to challenging naphthoquinones that are of relevance to lignan and… read more here.
Keywords: type polyketide; polyketide synthesis; lignan type; catalyzed cycloadditions ... See more keywords
Heterologous Biosynthesis of Type II Polyketide Products Using E. coli.
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DOI: 10.1021/acschembio.9b00827
Abstract: The heterologous biosynthesis of complex natural products has enabled access to polyketide, nonribosomal peptide, isoprenoid, and other compounds with wide-spanning societal value. Though several surrogate host systems exist, Escherichia coli is often a preferred choice… read more here.
Keywords: polyketide; type polyketide; biology; heterologous biosynthesis ... See more keywords
Discovering type I cis-AT polyketides through computational mass spectrometry and genome mining with Seq2PKS
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49587-1
Abstract: Type 1 polyketides are a major class of natural products used as antiviral, antibiotic, antifungal, antiparasitic, immunosuppressive, and antitumor drugs. Analysis of public microbial genomes leads to the discovery of over sixty thousand type 1… read more here.
Keywords: type; gene clusters; mass; type polyketide ... See more keywords