Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01709
Abstract: The emergence of drug-resistant HIV from a widespread antiviral chemotherapy targeting HIV protease in the past decades is unavoidable and provides a challenge to develop alternative inhibitors. We synthesized a series of allophenylnorstatine-based peptidomimetics with… read more here.
Keywords: highly potent; protease; type protease; allophenylnorstatine based ... See more keywords
Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma
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DOI: 10.1038/s41598-019-52609-4
Abstract: Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have… read more here.
Keywords: melanoma; kunitz type; protease inhibitor; protease ... See more keywords
Immunonutritional consequences of different serine-type protease inhibitors in a C57BL/6 hepatocarcinoma model
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DOI: 10.18632/oncotarget.26605
Abstract: Imbalances in innate immunity and the activity of innate immune cells are implicated in the development of hepatocellular carcinoma (HCC). Plant seeds are good sources of protease inhibitors, which can have a significant influence on… read more here.
Keywords: immunonutritional consequences; serine type; type protease; protease inhibitors ... See more keywords