Vandetanib drives growth arrest and promotes sensitivity to imatinib in chronic myeloid leukemia by targeting ephrin type‐B receptor 4
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13270
Abstract: The oncogenic role of ephrin type‐B receptor 4 (EPHB4) has been reported in many types of tumors, including chronic myeloid leukemia (CML). Here, we found that CML patients have a higher EPHB4 expression level than… read more here.
Keywords: imatinib; growth; ephrin type; vandetanib ... See more keywords
Cannabinoid Type 1 Receptor (CB1) Ligands with Therapeutic Potential for Withdrawal Syndrome in Chemical Dependents of Cannabis sativa
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700129
Abstract: Cannabis sativa withdrawal syndrome is characterized mainly by psychological symptoms. By using computational tools, the aim of this study was to propose drug candidates for treating withdrawal syndrome based on the natural ligands of the… read more here.
Keywords: cannabinoid type; type receptor; withdrawal syndrome; cannabis sativa ... See more keywords
Rational design of type-IA receptor-derived cyclic peptides to target human bone morphogenic protein 2
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biosciences"
DOI: 10.1007/s12038-019-9945-8
Abstract: Human bone morphogenetic protein 2 (BMP2) is a bone-growth regulatory factor involved in the formation of bone and cartilage, and has been recognized as an attractive therapeutic target for a variety of bone diseases and… read more here.
Keywords: type receptor; cyclic peptide; human bone; bone ... See more keywords
Bovine dopamine type-2 receptor SNP has no effect on growth, semen characteristics and prolactin concentrations in beef bulls treated with a dopamine agonist.
Sign Up to like & getrecommendations! Published in 2019 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2019.06.005
Abstract: A dopamine type-2 receptor (DRD2) SNP, previously found to be correlated with serum prolactin (PRL) concentrations in cattle, was evaluated for impact on growth traits, serum prolactin concentration, and semen quality. Over a four-year period,… read more here.
Keywords: type receptor; prl; beef bulls; dopamine type ... See more keywords
Blockade of the angiotensin II type 1 receptor increases bone mineral density and left ventricular contractility in a mouse model of juvenile paget disease.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172519
Abstract: Juvenile Paget disease (JPD1), an autosomal-recessive disorder, is characterized by extremely rapid bone turnover due to osteoprotegerin deficiency. Its extra-skeletal manifestations, such as hypertension and heart failure, suggest a pathogenesis with shared skeletal and cardiovascular… read more here.
Keywords: angiotensin infusion; angiotensin type; type receptor; angiotensin ... See more keywords
Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.12.011
Abstract: Introduction Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non–human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies… read more here.
Keywords: hla dsa; type receptor; profiles associated; angiotensin type ... See more keywords
Preoperative angiotensin II type 2 receptor is a predictor for developing chronic post-surgical pain after total knee arthroplasty surgery.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119654
Abstract: OBJECTIVE This study aimed to explore whether preoperative angiotensin II type 2 receptor (AT2R) level in knee osteoarthritis (OA) patients was an independent risk factor for chronic post-surgical pain (CPSP) after total knee arthroplasty (TKA).… read more here.
Keywords: type receptor; surgery; knee; preoperative angiotensin ... See more keywords
Label‐free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time‐resolved G‐protein activity and distinct AngII and AngIIIIV responses
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.06.027
Abstract: ABSTRACT Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein‐coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein… read more here.
Keywords: type receptor; response; label free; angiotensin ... See more keywords
The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.12.003
Abstract: Angiotensin II (AngII) is a peptide hormone that plays a key role in regulating blood pressure, and its interactions with the G protein-coupled receptors, AngII type-1 receptor (AT1R) and AngII type-2 receptor (AT2R), are central… read more here.
Keywords: type receptor; crystal structure; angiotensin; receptor ... See more keywords
Histopathological Relevance of Angiotensin II Type 1 Receptor in Renal Transplant Biopsy.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.137
Abstract: The occurrence of anti-angiotensin II type 1 receptor (AT1R) antibodies is thought to be a risk factor for transplant injury, but the relationship of AT1R to graft loss in renal transplantation has not been assessed.… read more here.
Keywords: type receptor; biopsy; at1r; renal transplant ... See more keywords
Trans and Cis Conformations of the Antihypertensive Drug Valsartan Respectively Lock the Inactive and Active-like States of Angiotensin II Type 1 Receptor: A Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00364
Abstract: Angiotensin II type 1 receptor (AT1R) is the principal regulator of blood pressure in humans. The overactivation of AT1R by the stimulation of angiotensin II would result in high blood pressure. To prevent hypertension, nonpeptide… read more here.
Keywords: type receptor; at1r; trans cis; cis conformations ... See more keywords