Autoantibodies against ACE2 and angiotensin type-1 receptors increase severity of COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Autoimmunity"
DOI: 10.1016/j.jaut.2021.102683
Abstract: The renin-angiotensin system (RAS) plays a major role in COVID-19. Severity of several inflammation-related diseases has been associated with autoantibodies against RAS, particularly agonistic autoantibodies for angiotensin type-1 receptors (AA-AT1) and autoantibodies against ACE2 (AA-ACE2).… read more here.
Keywords: severity; autoantibodies ace2; type receptors; angiotensin type ... See more keywords
Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02163
Abstract: Despite the therapeutic relevance of δ-containing γ-aminobutyric acid type A receptors (GABAARs) and the need for δ-selective compounds, the structural determinants for the mode and molecular site of action of δ-selective positive allosteric modulator imidazo[1,2-a]pyridine… read more here.
Keywords: ds2; acid type; type receptors; containing aminobutyric ... See more keywords
Conformationally mobile acyclic cucurbit[n]uril-type receptors derived from an S-shaped methylene bridged glycoluril pentamer
Sign Up to like & getrecommendations! Published in 2020 at "Supramolecular Chemistry"
DOI: 10.1080/10610278.2020.1795173
Abstract: ABSTRACT We report the synthesis of the conformationally mobile S-shaped glycoluril pentamer building block 3a and two new acyclic CB[n]-type receptors P1 and P2. P1 (9 mM) and P2 (11 mM) have moderate aqueous solubility… read more here.
Keywords: glycoluril pentamer; shaped methylene; methylene bridged; bridged glycoluril ... See more keywords
Sustained and Transient Vestibular Systems: A Physiological Basis for Interpreting Vestibular Function
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2017.00117
Abstract: Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the… read more here.
Keywords: sustained transient; vibration; irregular afferents; 500 vibration ... See more keywords