Enhancement of Graft-Versus-Host Disease Control Efficacy by Adoptive Transfer of Type 1 Regulatory T Cells in Bone Marrow Transplant Model.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells and development"
DOI: 10.1089/scd.2018.0113
Abstract: Interleukin (IL)-10-producing type 1 regulatory T (Tr1) cells, which are Foxp3-memory T lymphocytes, play important roles in peripheral immune tolerance. We investigated whether Tr1 cells exert immunoregulatory effects in a mouse model of acute graft-versus-host… read more here.
Keywords: type regulatory; tr1 cells; tr1; versus host ... See more keywords
Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo4413
Abstract: Type 1 regulatory T (Tr1) cells represent a subset of IL-10–producing CD4+Foxp3− T cells and play key roles in promoting transplant tolerance. However, no effective pharmacological approaches have been able to induce Tr1 cells in… read more here.
Keywords: tr1; permanent allograft; allograft acceptance; cd28 superagonist ... See more keywords
Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization
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DOI: 10.1371/journal.pbio.3003262
Abstract: Cyclic adenosine monophosphate (cAMP), a ubiquitous second messenger, regulates a variety of cellular functions with high specificity. We previously showed that the type I regulatory subunit of cAMP-dependent protein kinase A (PKA), RIα, undergoes liquid–liquid… read more here.
Keywords: type regulatory; phase separation; function; regulatory subunit ... See more keywords
Type 1 regulatory T cell-mediated tolerance in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032575
Abstract: Type 1 regulatory T (Tr1) cells, in addition to other regulatory cells, contribute to immunological tolerance to prevent autoimmunity and excessive inflammation. Tr1 cells arise in the periphery upon antigen stimulation in the presence of… read more here.
Keywords: tr1; disease; mediated tolerance; tr1 cells ... See more keywords