Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ginseng Research"
DOI: 10.1016/j.jgr.2017.01.001
Abstract: Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of… read more here.
Keywords: ocotillol type; discovery semisynthesis; biological activities; type saponins ... See more keywords
Dammarane-type saponins from the leaves of Panax notoginseng and their neuroprotective effects on damaged SH-SY5Y cells.
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2017.09.020
Abstract: Seven dammarane-type saponins previously undescribed (notoginsenosides Fh1-Fh7) were isolated from the aqueous extract leaves of Panax notoginseng (Burk.) F.H.Chen (Araliaceae), together with eleven known saponins. Their structures of were elucidated by spectroscopic analysis (NMR, UV,… read more here.
Keywords: leaves panax; neuroprotective effects; panax notoginseng; dammarane type ... See more keywords
New 20(S)-protopanaxadiol type saponins from the leaves of Panax notoginseng and their potential anti-inflammatory activities
Sign Up to like & getrecommendations! Published in 2020 at "Steroids"
DOI: 10.1016/j.steroids.2020.108696
Abstract: Through the combination of various chromatographies, 11 new 20(S)-protopanaxadiol (PPD) type saponins, named as notoginsenosides NL-E1-NL-E4 (1-4), NL-F1 (5), NL-F2 (6), NL-G1 (7), NL-G2 (8), NL-H1-NL-H3 (9-11) were obtained from the leaves of Panax notoginseng.… read more here.
Keywords: leaves panax; protopanaxadiol type; panax notoginseng; new protopanaxadiol ... See more keywords
High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2021 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2021.04.006
Abstract: The Chinese medicinal plant Panax notoginseng has been traditionally used to activate blood flow and circulation, and to prevent blood stasis. P. notoginseng contains protopanaxatriol (PPT)-type saponins as its main active compounds, thus distinguishing it… read more here.
Keywords: production; ppt; ppt type; rg1 ... See more keywords
Discovery, Preliminary Structure-Activity Relationship, and Evaluation of Oleanane-Type Saponins from Pulsatilla chinensis for the Treatment of Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00112
Abstract: To discover ulcerative colitis (UC) treatment agents, 28 oleanane-type triterpenoid saponins (1-28) including three new saponins, pulsatillosides P-R (1-3), were isolated from Pulsatilla chinensis. The isolated saponins could observably ameliorate UC by improving the intestinal… read more here.
Keywords: oleanane type; treatment; type saponins; chinensis ... See more keywords
Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.845034
Abstract: Ginsenosides from ginseng are used as a therapeutic agent for various diseases. They enhance the immunomodulatory effect in cyclophosphamide (CP)-treated tumor disease. The structural characteristics of steroidal saponins are mainly divided into protopanaxadiol-type saponin (PDS)… read more here.
Keywords: mice induced; type; effect; type saponins ... See more keywords