A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301929
Abstract: Ionizable lipid-based nanoparticles (LNPs) are the most advanced non-viral drug delivery systems for RNA therapeutics and vaccines. However, cell type-specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel therapeutic modalities.… read more here.
Keywords: type specific; delivery; mrna delivery; cell type ... See more keywords
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506109
Abstract: Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, we developed human cell-type-specific transcriptomic aging clocks using high-quality single-nucleus RNA sequencing data from… read more here.
Keywords: type specific; aging clocks; brain; cell ... See more keywords
The Molecular Toolbox for Linkage Type‐Specific Analysis of Ubiquitin Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Chembiochem"
DOI: 10.1002/cbic.202500114
Abstract: Modification of proteins and other biomolecules with ubiquitin regulates virtually all aspects of eukaryotic cell biology. Ubiquitin can be attached to substrates as a monomer or as an array of polyubiquitin chains with defined linkages… read more here.
Keywords: type specific; molecular toolbox; linkage type; linkage ... See more keywords
Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24733
Abstract: Endocannabinoids and their receptors are highly abundant in the developing cerebral cortex and play major roles in early developmental processes, for example, neuronal proliferation, migration, and axonal guidance as well as postnatal plasticity. To investigate… read more here.
Keywords: type specific; barrel; map; cb1 ... See more keywords
HPV type‐specific trends in cervical precancers in the United States, 2008 to 2016
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34231
Abstract: Declines in cervical intraepithelial neoplasia grades 2 to 3 and adenocarcinoma in situ (CIN2+) observed among young women suggest impact from human papillomavirus (HPV) vaccination. To further evaluate vaccine impact including cross‐protection and type replacement,… read more here.
Keywords: hpv16 cin2; cin2; type specific; hpv ... See more keywords
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12183
Abstract: Abstract In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human‐induced pluripotent stem cell‐derived… read more here.
Keywords: disease; type specific; brain; cell type ... See more keywords
Benchmarking transcriptome deconvolution methods for estimating tissue‐ and cell‐type‐specific extracellular vesicle abundances
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12511
Abstract: Abstract Extracellular vesicles (EVs) contain cell‐derived lipids, proteins and RNAs; however, determining the tissue‐ and cell‐type‐specific EV abundances in body fluids remains a significant hurdle for our understanding of EV biology. While tissue‐ and cell‐type‐specific… read more here.
Keywords: type specific; cell; tissue cell; deconvolution ... See more keywords
A Chemogenetic Toolkit for Inducible, Cell Type‐Specific Actin Disassembly
Sign Up to like & getrecommendations! Published in 2025 at "Small Methods"
DOI: 10.1002/smtd.202401522
Abstract: The actin cytoskeleton and its nanoscale organization are central to all eukaryotic cells—powering diverse cellular functions including morphology, motility, and cell division—and is dysregulated in multiple diseases. Historically studied largely with purified proteins or in… read more here.
Keywords: type specific; actin disassembly; cell; actin ... See more keywords
UV-B response is modulated by cell-type specific signaling pathway in multicellular green algae Volvox carteri
Sign Up to like & getrecommendations! Published in 2018 at "Plant Growth Regulation"
DOI: 10.1007/s10725-018-0472-7
Abstract: A fundamental question in biology is how multicellular organisms regulate cellular and physiological processes in response to environmental signals in a tissue/cell type-specific manner. Light is one such cue but little is known about its… read more here.
Keywords: specific signaling; type specific; response; cell ... See more keywords
Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1346-8
Abstract: CDKL5 disorder is a devastating neurodevelopmental disorder associated with epilepsy, developmental retardation, autism, and related phenotypes. Mutations in the CDKL5 gene, encoding CDKL5, have been identified in this disorder. CDKL5 is a protein with homology… read more here.
Keywords: type specific; neuron type; mtor signaling; loss cdkl5 ... See more keywords
Sex- and cell type-specific effects of dexmedetomidine on ferroptosis in neurons and microglia following traumatic brain injury in juvenile mice
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-05281-x
Abstract: Ferroptosis plays a key role in neuronal death and functional outcomes following traumatic brain injury (TBI). While TBI affects diverse cell types in injured brain regions, the sex- and cell type-specific responses to ferroptosis during… read more here.
Keywords: type specific; cell; sex cell; cell type ... See more keywords