A Combinatorial Library of Lipid Nanoparticles for Cell Type-Specific mRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301929
Abstract: Ionizable lipid-based nanoparticles (LNPs) are the most advanced non-viral drug delivery systems for RNA therapeutics and vaccines. However, cell type-specific, extrahepatic mRNA delivery is still a major hurdle, hampering the development of novel therapeutic modalities.… read more here.
Keywords: type specific; delivery; mrna delivery; cell type ... See more keywords
Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24733
Abstract: Endocannabinoids and their receptors are highly abundant in the developing cerebral cortex and play major roles in early developmental processes, for example, neuronal proliferation, migration, and axonal guidance as well as postnatal plasticity. To investigate… read more here.
Keywords: type specific; barrel; map; cb1 ... See more keywords
HPV type‐specific trends in cervical precancers in the United States, 2008 to 2016
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34231
Abstract: Declines in cervical intraepithelial neoplasia grades 2 to 3 and adenocarcinoma in situ (CIN2+) observed among young women suggest impact from human papillomavirus (HPV) vaccination. To further evaluate vaccine impact including cross‐protection and type replacement,… read more here.
Keywords: hpv16 cin2; cin2; type specific; hpv ... See more keywords
Human neural cell type‐specific extracellular vesicle proteome defines disease‐related molecules associated with activated astrocytes in Alzheimer's disease brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12183
Abstract: Abstract In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human‐induced pluripotent stem cell‐derived… read more here.
Keywords: disease; type specific; brain; cell type ... See more keywords
UV-B response is modulated by cell-type specific signaling pathway in multicellular green algae Volvox carteri
Sign Up to like & getrecommendations! Published in 2018 at "Plant Growth Regulation"
DOI: 10.1007/s10725-018-0472-7
Abstract: A fundamental question in biology is how multicellular organisms regulate cellular and physiological processes in response to environmental signals in a tissue/cell type-specific manner. Light is one such cue but little is known about its… read more here.
Keywords: specific signaling; type specific; response; cell ... See more keywords
Neuron-Type Specific Loss of CDKL5 Leads to Alterations in mTOR Signaling and Synaptic Markers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1346-8
Abstract: CDKL5 disorder is a devastating neurodevelopmental disorder associated with epilepsy, developmental retardation, autism, and related phenotypes. Mutations in the CDKL5 gene, encoding CDKL5, have been identified in this disorder. CDKL5 is a protein with homology… read more here.
Keywords: type specific; neuron type; mtor signaling; loss cdkl5 ... See more keywords
An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABAA Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.09.025
Abstract: Summary Inhibitory synaptic transmission requires the targeting and stabilization of GABAA receptors (GABAARs) at synapses. The mechanisms responsible remain poorly understood, and roles for transmembrane accessory proteins have not been established. Using molecular, imaging, and… read more here.
Keywords: tetraspanin lhfpl4; type specific; gabaa receptors; cell type ... See more keywords
Cell-Type-Specific Thalamocortical Inputs Constrain Direction Map Formation in Visual Cortex.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.008
Abstract: Finding the relationship between individual cognitive functions and cell-type-specific neuronal circuits is a central topic in neuroscience. In cats, the lateral geniculate nucleus (LGN) contains several cell types carrying spatially and temporally precise visual information. Whereas… read more here.
Keywords: direction; type specific; cell types; cell ... See more keywords
Sublayer- and cell-type-specific neurodegenerative transcriptional trajectories in hippocampal sclerosis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109229
Abstract: Hippocampal sclerosis, the major neuropathological hallmark of temporal lobe epilepsy, is characterized by different patterns of neuronal loss. The mechanisms of cell-type-specific vulnerability and their progression and histopathological classification remain controversial. Using single-cell electrophysiology in vivo… read more here.
Keywords: type specific; cell; cell type; hippocampal sclerosis ... See more keywords
Viral vectors for neuronal cell type-specific visualization and manipulations
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2020.03.011
Abstract: Characterizing neuronal cell types demands efficient strategies for specific labeling and manipulation of individual subtypes to dissect their connectivity and functions. Recombinant viral technology offers a powerful toolbox for targeted transgene expression in specific neuronal… read more here.
Keywords: viral vectors; type specific; neuronal cell; cell ... See more keywords
Cell‐Type‐Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2018.12.012
Abstract: &NA; Interleukin‐1 (IL‐1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell‐type‐specific roles of IL‐1 signaling are unclear. We used a genetic knockin reporter system in mice… read more here.
Keywords: receptor; type specific; cell type; cns ... See more keywords