Synthesis of Hemicatenanes for the Study of Type IA Topoisomerases.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7459-7_11
Abstract: Hemicatenane is a structure that forms when two DNA duplexes are physically linked through a single-stranded crossover. It is proposed to be an intermediate resulting from double Holliday junction (dHJ) dissolution, repair of replication stalled… read more here.
Keywords: type topoisomerases; hemicatenanes study; study type; hemicatenane ... See more keywords
Two type I topoisomerases maintain DNA topology in human mitochondria
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DOI: 10.1093/nar/gkac857
Abstract: Abstract Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a… read more here.
Keywords: topology; type topoisomerases; topoisomerases maintain; top3a top1mt ... See more keywords
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
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DOI: 10.1093/nar/gkad190
Abstract: To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this complex is a requisite enzyme intermediate, it is also intrinsically dangerous to genomic stability. Consequently, cleavage… read more here.
Keywords: supercoil handedness; type topoisomerases; cleavage; dna ... See more keywords
A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents
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DOI: 10.1093/nar/gkz579
Abstract: Abstract Type II topoisomerases catalyze essential DNA transactions and are proven drug targets. Drug discrimination by prokaryotic and eukaryotic topoisomerases is vital to therapeutic utility, but is poorly understood. We developed a next-generation sequencing (NGS)… read more here.
Keywords: type topoisomerases; drug; sensitivity; complex suite ... See more keywords
Supercoiling, R-Loops, Replication and the Functions of Bacterial Type 1A Topoisomerases
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DOI: 10.3390/genes11030249
Abstract: Type 1A topoisomerases (topos) are the only topos that bind single-stranded DNA and the only ones found in all cells of the three domains of life. Two subfamilies, topo I and topo III, are present… read more here.
Keywords: type topoisomerases; functions bacterial; bacterial type; topo iii ... See more keywords