Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52429-6
Abstract: Phasevarions (phase-variable regulons) are emerging as an important area of bacterial gene regulation. Many bacterial pathogens contain phasevarions, with gene expression controlled by the phase-variable expression of DNA methyltransferases via epigenetic mechanisms. Non-typeable Haemophilus influenzae… read more here.
Keywords: haemophilus influenzae; non typeable; phase variable; typeable haemophilus ... See more keywords
Examination of phase-variable haemoglobin–haptoglobin binding proteins in non-typeable Haemophilus influenzae reveals a diverse distribution of multiple variants
Sign Up to like & getrecommendations! Published in 2022 at "FEMS Microbiology Letters"
DOI: 10.1093/femsle/fnac064
Abstract: Abstract Non-typeable Haemophilus influenzae (NTHi) is a major human pathogen for which there is no globally licensed vaccine. NTHi has a strict growth requirement for iron and encodes several systems to scavenge elemental iron and… read more here.
Keywords: typeable haemophilus; haemophilus influenzae; binding proteins; non typeable ... See more keywords
Antimicrobial activity of a novel bioengineered honey against non-typeable Haemophilus influenzae biofilms: an in vitro study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2017-204901
Abstract: The opportunistic pathogen non-typeable Haemophilus influenzae (NTHi) plays an important role in many chronic respiratory diseases including otitis media, chronic rhinosinusitis, cystic fibrosis and chronic obstructive pulmonary disease. Biofilm formation has been implicated in NTHi… read more here.
Keywords: typeable haemophilus; haemophilus influenzae; non typeable;
Primary ciliary dyskinesia exhibits dysregulated epithelial responses to non-typeable Haemophilus influenzae
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DOI: 10.1183/1393003.congress-2017.oa4628
Abstract: Background: PCD is an inherited heterogenous disorder of impaired mucociliary clearance. Early colonisation of the lower airways with non-typeable Haemophilus influenzae (NTHi) is common. Chronic inflammation and recurrent infections inevitably lead to irreversible bronchiectasis. It… read more here.
Keywords: haemophilus influenzae; non typeable; pcd; typeable haemophilus ... See more keywords
Non-typeable Haemophilus influenzae infection of ciliated epithelium from healthy and chronic obstructive pulmonary disease donors
Sign Up to like & getrecommendations! Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa5300
Abstract: Background: Non-typeable Haemophilus influenzae (NTHi) is strongly associated with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). Little is known about initial NTHi-host interactions and how this leads to colonisation. Therefore, we investigated early NTHi interaction… read more here.
Keywords: chronic obstructive; haemophilus influenzae; microscopy; obstructive pulmonary ... See more keywords
Essential role of IL-17 in acute exacerbation of pulmonary fibrosis induced by non-typeable Haemophilus influenzae
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DOI: 10.7150/thno.74809
Abstract: Background: Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) has a poor prognosis and lacks effective therapy. Animal models that mimic AE-IPF can greatly accelerate investigation of its pathogenesis and development of effective therapy. However,… read more here.
Keywords: ipf; typeable haemophilus; pulmonary fibrosis; acute exacerbation ... See more keywords