Mechanisms of typhoid toxin neutralization by antibodies targeting glycan receptor binding and nuclease subunits
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DOI: 10.1016/j.isci.2021.102454
Abstract: Summary Nearly all clinical isolates of Salmonella Typhi, the cause of typhoid fever, are antibiotic resistant. All S. Typhi isolates secrete an A2B5 exotoxin called typhoid toxin to benefit the pathogen during infection. Here, we… read more here.
Keywords: targeting glycan; glycan receptor; toxin; antibodies targeting ... See more keywords
Peptidoglycan editing by a specific ld-transpeptidase controls the muramidase-dependent secretion of typhoid toxin
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DOI: 10.1038/s41564-018-0248-x
Abstract: Protein secretion mechanisms are essential for the virulence of most bacterial pathogens. Typhoid toxin is an essential virulence factor for Salmonella Typhi, the cause of typhoid fever in humans. This toxin is unique in that… read more here.
Keywords: secretion typhoid; transpeptidase; toxin; typhoid toxin ... See more keywords
Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
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DOI: 10.1128/iai.00292-20
Abstract: Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5… read more here.
Keywords: monoclonal antibodies; toxin neutralizing; toxin; generation characterization ... See more keywords
Molecular Insights into the Assembly and Functional Diversification of Typhoid Toxin
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DOI: 10.1128/mbio.01916-21
Abstract: Typhoid fever is a devastating disease that kills more than 115,000 people every year and is caused by Salmonella Typhi. Typhoid toxin, exclusively produced by S. ABSTRACT Typhoid toxin is an A2B5 protein toxin and… read more here.
Keywords: typhoid toxin; typhoid; pltc; typhoid fever ... See more keywords