Thermodynamic consequences of Tyr to Trp mutations in the cation–π-mediated binding of trimethyllysine by the HP1 chromodomain†
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DOI: 10.1039/d0sc00227e
Abstract: Evolution has converged on cation–π interactions for recognition of quaternary alkyl ammonium groups such as trimethyllysine (Kme3). While computational modelling indicates that Trp provides the strongest cation–π interaction of the native aromatic amino acids, there… read more here.
Keywords: cation interaction; cation; thermodynamic consequences; hp1 chromodomain ... See more keywords
UVB-Induced Secretion of IL-1β Promotes Melanogenesis by Upregulating TYR/TRP-1 Expression In Vitro
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DOI: 10.1155/2022/8230646
Abstract: Purpose Ultraviolet radiation (UVR) is one of the exogenous stimuli increasing melanogenesis. UV light, especially UVB, is also a potent inducer of epidermal cytokine release. This study is aimed at determining the underlying mechanisms by… read more here.
Keywords: b16 cells; uvb induced; expression levels; expression ... See more keywords
A Plausible Entry to 20 Proteinogenic Amino Acids via Aminomalononitrile Derivatives
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DOI: 10.1177/1934578x231175261
Abstract: Dear Editor, It is not yet known why the number of proteinogenic amino acids is limited to 20. Some explanations for this problem have been attempted, but it is still unresolved. Aminomalononitrile is a hydrogen… read more here.
Keywords: amino acids; proteinogenic amino; phe tyr; side ... See more keywords