The TAM receptor Tyro3 regulates myelination in the central nervous system
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DOI: 10.1002/glia.23113
Abstract: Myelin is an essential component of the mammalian nervous system, facilitating rapid conduction of electrical impulses by axons, as well as providing trophic support to neurons. Within the central nervous system, the oligodendrocyte is the… read more here.
Keywords: gas6; nervous system; central nervous; myelination ... See more keywords
Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis
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DOI: 10.1126/sciadv.ade3422
Abstract: Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, the underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase is a… read more here.
Keywords: metastasis; brd3; nuclear tyro3; tyro3 ... See more keywords
Functional Genomics Identifies Hepatitis-Induced STAT3–TYRO3–STAT3 Signaling as a Potential Therapeutic Target of Hepatoma
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DOI: 10.1158/1078-0432.ccr-18-3531
Abstract: Purpose: Hepatitis promotes the development and recurrence of hepatocellular carcinoma (HCC). Receptor tyrosine kinases (RTK) play critical roles in the development of many cancers. We explored the potential roles of RTKs in hepatitis-related liver cancers.… read more here.
Keywords: stat3; hcc; development; tyro3 ... See more keywords
Abstract 2879: TYRO3 is a potential therapeutic target in pediatric acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-2879
Abstract: BACKGROUND: While outcomes for children with acute myeloid leukemia have improved dramatically in recent years, a subset of patients continue to have poor prognosis with METHODS: The TARGET database was utilized to determine expression of… read more here.
Keywords: myeloid leukemia; acute myeloid; therapeutic target; target ... See more keywords
Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis
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DOI: 10.1164/rccm.201707-1519oc
Abstract: Rationale: Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling, which progressively abolishes lung function in an RTK (receptor tyrosine kinase)‐dependent manner. Gas6 (growth arrest‐specific 6) ligand, Tyro3 (TYRO3 protein tyrosine kinase 3), and… read more here.
Keywords: fibrosis; idiopathic pulmonary; pulmonary fibrosis; receptor ... See more keywords
Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells
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DOI: 10.3390/biom10071035
Abstract: The TAM (Tyro3, Axl, MerTK) subfamily of receptor tyrosine kinases (RTKs) and their ligands, Gas6 and protein S (ProS1), are implicated in tumorigenesis and chemoresistance in various cancers. The β-galactoside binding protein galectin-3 (Gal-3), which… read more here.
Keywords: erk; migration; cancer cells; cancer ... See more keywords